ArticleInternational journal of molecular sciences2023
Relevance of Biomarkers in Serum vs. Synovial Fluid in Patients with Knee Osteoarthritis.
Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 19 citations in OpenAlex.
- Effects of pentosan polysulfate sodium on synovial fluid biomarkers in moderate to severe knee osteoarthritis: an exploratory, phase 2, randomized, double-blind, placebo-controlled trial.Arthritis research & therapy · 2026Trial
- Osteoarthritis pain inversely correlates with histidine and glutamine following CSF and serum profiling.Arthritis research & therapy · 2026Article
- Preliminary IL-1 Family Cytokine Signature for Crohn's Disease Onset in Pediatric Juvenile Idiopathic Arthritis.International journal of molecular sciences · 2026Article
- Extracellular matrix remodeling in the pathogenesis and therapeutic strategies of rheumatoid arthritis.Clinical and experimental medicine · 2026Review
- Production of a risk mitigation matrix and four-grade threshold scale using Cox Regression to predict osteoarthritis development.Open life sciences · 2026Article
- A Multidimensional Definition of Pre-Osteoarthritis: Toward 21st-Century Subclinical Detection and Targeted Intervention.International journal of molecular sciences · 2025Review
- Intra-articular hexagonal boron nitride-hyaluronic acid composite hydrogels rebalance cytokine profiles and enhance extracellular matrix regeneration in a rabbit osteoarthritis model.Inflammopharmacology · 2025Article
- Serum phospholipids and sphingolipids are linked to early-stage osteoarthritis by lipidomic profiling.Arthritis research & therapy · 2025Article
- Osteopontin inhibits autophagy via CD44 and avβ3 integrin and promotes cell proliferation in osteoarthritic fibroblast-like synoviocytes.BMC musculoskeletal disorders · 2025Article
- Preliminary Study for the Early Diagnosis of Osteoarthritis in Human Synovial Fluid Using ATR-FTIR Combined with Chemometrics.The archives of bone and joint surgery · 2025Article
- Osteoarthritis Year in Review 2024: Molecular biomarkers of osteoarthritis.Osteoarthritis and cartilage · 2025Review
- Catabolic mediators from TLR2-mediated proteoglycan aggrecan peptide-stimulated chondrocytes are reduced by Lactobacillus-conditioned media.Scientific reports · 2024Article
- Utilising Discriminant Function Analysis (DFA) for Classifying Osteoarthritis (OA) Patients and Volunteers Based on Biomarker Concentration.Diagnostics (Basel, Switzerland) · 2024Article
- Correlation of the total superoxide dismutase activity between joint fluid and synovium in end-stage knee osteoarthritis.Scientific reports · 2024Article
- A comprehensive patient-specific prediction model for temporomandibular joint osteoarthritis progression.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- In Vivo Evaluation of Collagen and Chitosan Scaffold, Associated or Not with Stem Cells, in Bone Repair.Journal of functional biomaterials · 2023Article
- Soluble Proteoglycans and Proteoglycan Fragments as Biomarkers of Pathological Extracellular Matrix Remodeling.Proteoglycan researchReview
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
The association between structural changes and pain sensation in osteoarthritis (OA) remains unclear. Joint deterioration in OA leads to the release of protein fragments that can either systemically (serum) or locally (synovial fluid; SF) be targeted as biomarkers and describe structural changes and potentially pain. Biomarkers of collagen type I (C1M), type II (C2M), type III (C3M), type X (C10C), and aggrecan (ARGS) degradation were measured in the serum and SF of knee OA patients. Spearman's rank correlation was used to assess the correlation of the biomarkers' levels between serum and SF. Linear regression adjusted for confounders was used to evaluate the associations between the biomarkers' levels and clinical outcomes. The serum C1M levels were negatively associated with subchondral bone density. The serum C2M levels were negatively associated with KL grade and positively associated with minimum joint space width (minJSW). The C10C levels in SF were negatively associated with minJSW and positively associated with KL grade and osteophyte area. Lastly, the serum C2M and C3M levels were negatively associated with pain outcomes. Most of the biomarkers seemed to mainly be associated with structural outcomes. The overall biomarkers of extracellular matrix (ECM) remodeling in serum and SF may provide different information and reflect different pathogenic processes.
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Registered trials
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