Evidence map›Paper›PMID 37298375›Full record

ArticleInternational journal of molecular sciences2023

Investigating the Contribution of Major Drug-Metabolising Enzymes to Possum-Specific Fertility Control.

Ravneel R Chand, Mhairi Nimick, Belinda Cridge, Rhonda J Rosengren

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Ravneel R ChandDepartment of Pharmacology and Toxicology, School of Biomedical Sciences, University of Otago, Dunedin 9016, New Zealand.
Mhairi NimickDepartment of Pharmacology and Toxicology, School of Biomedical Sciences, University of Otago, Dunedin 9016, New Zealand.ORCID 0000-0002-3351-0897
Belinda CridgeScience for Communities, Christchurch Science Centre, Christchurch 8041, New Zealand.
Rhonda J RosengrenDepartment of Pharmacology and Toxicology, School of Biomedical Sciences, University of Otago, Dunedin 9016, New Zealand.
University of Otago · NZChristchurch Clinical Studies Trust · NZ

Funding

Operational Solutions for Primary Industries PL.11511501.P.LM
6 · The paper itself

Abstract

The potential to improve the effectiveness and efficiency of potential oestrogen-based oral contraceptives (fertility control) for possums was investigated by comparing the inhibitory potential of hepatic CYP3A and UGT2B catalytic activity using a selected compound library (CYP450 inhibitor-based compounds) in possums to that of three other species (mouse, avian, and human). The results showed higher CYP3A protein levels in possum liver microsomes compared to other test species (up to a 4-fold difference). Moreover, possum liver microsomes had significantly higher basal

Indexed as

Cytochrome P-450 CYP3AMicrosomes, LiverAnimalsContraceptionHumansKetoconazoleLiverMiceCytochrome P-450 CYP3AKetoconazolebrushtail possumdrug-metabolising enzymes (CYP3A and UGT2B)fertility controlTrichosurus vulpecula

Identifiers

PMID37298375
PMCPMC10253456
OpenAlexW4378716582

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.