Evidence map›Paper›PMID 37298349›Full record

ArticleInternational journal of molecular sciences2023

A Non-Systemic Phosphodiesterase-5 Inhibitor Suppresses Colon Proliferation in Mice.

Avelina Lee, Iryna Lebedyeva, Wenbo Zhi, Vani Senthil, Herjot Cheema, Michael W Brands, Weston Bush, Nevin A Lambert, Madeline Snipes, Darren D Browning

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Avelina LeeDepartment of Biochemistry and Molecular Biology, Augusta University, Augusta, GA 30912, USA.ORCID 0009-0003-3630-0611
Iryna LebedyevaDepartment of Chemistry and Physics, Augusta University, Augusta, GA 30912, USA.
Wenbo ZhiCenter for Biotechnology and Genomic Medicine, Augusta University, Augusta, GA 30912, USA.ORCID 0000-0002-7720-7048
Vani SenthilDepartment of Biochemistry and Molecular Biology, Augusta University, Augusta, GA 30912, USA.
Herjot CheemaDepartment of Biochemistry and Molecular Biology, Augusta University, Augusta, GA 30912, USA.
Michael W BrandsDepartment of Physiology, Augusta University, Augusta, GA 30912, USA.
Weston BushDepartment of Physiology, Augusta University, Augusta, GA 30912, USA.
Nevin A LambertDepartment of Pharmacology and Toxicology, Augusta University, Augusta, GA 30912, USA.
Madeline SnipesDepartment of Biochemistry and Molecular Biology, Augusta University, Augusta, GA 30912, USA.
Darren D BrowningDepartment of Biochemistry and Molecular Biology, Augusta University, Augusta, GA 30912, USA.ORCID 0000-0003-0497-7620
Augusta University · US

Funding

Development of PDE5 Inhibitors for Localized Delivery to Prevent Colorectal CancerR15CA264555 · NCI · AUGUSTA UNIVERSITY · PI MIAO, SHAOBIN · 2021 to 2021
$439k
Colon cancer prevention with non-systemic PDE5 inhibitorsR41CA272072 · NCI · TARGUT BIOTECHNOLOGIES INC. · PI BROWNING, DARREN D. · 2022 to 2022
$192k
NCI NIH HHS R41 CA272072NIH HHS 1 R15 CA264555-01
6 · The paper itself

Abstract

Phosphodiesterase-5 inhibitors (PDE5i) are under investigation for repurposing for colon cancer prevention. A drawback to conventional PDE5i are their side-effects and drug-drug interactions. We designed an analog of the prototypical PDE5i sildenafil by replacing the methyl group on the piperazine ring with malonic acid to reduce lipophilicity, and measured its entry into the circulation and effects on colon epithelium. This modification did not affect pharmacology as malonyl-sildenafil had a similar IC

Indexed as

Colonic NeoplasmsPhosphodiesterase 5 InhibitorsAnimalsCell ProliferationChromatography, LiquidCyclic GMPCyclic Nucleotide Phosphodiesterases, Type 5MiceSildenafil CitrateTandem Mass SpectrometryCyclic GMPCyclic Nucleotide Phosphodiesterases, Type 5Phosphodiesterase 5 InhibitorsSildenafil Citratecolon neoplasmscyclic guanosine monophosphateintestinespharmacokineticsphosphodiesterase inhibitor

Identifiers

PMID37298349
PMCPMC10253591
OpenAlexW4378619320

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.