Evidence map›Paper›PMID 37298287›Full record

ArticleInternational journal of molecular sciences2023

Resistance to Resveratrol Treatment in Experimental PTSD Is Associated with Abnormalities in Hepatic Metabolism of Glucocorticoids.

Vadim E Tseilikman, Julia O Fedotova, Olga B Tseilikman, Jurica Novak, Marina N Karpenko, Victoria A Maistrenko, Svetlana S Lazuko, Lyudmila E Belyeva, Mustapha Kamel, Alexey V Buhler and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.1field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 3 countries.

Vadim E TseilikmanScientific and Educational Center 'Biomedical Technologies', School of Medical Biology, South Ural State University, 454080 Chelyabinsk, Russia.
Julia O FedotovaLaboratory of Neuroendocrinology, I.P. Pavlov Institute of Physiology RAS, 6 Emb. Makarova, 199034 Saint Petersburg, Russia.ORCID 0000-0002-3117-9299
Olga B TseilikmanScientific and Educational Center 'Biomedical Technologies', School of Medical Biology, South Ural State University, 454080 Chelyabinsk, Russia.
Jurica NovakDepartment of Biotechnology, University of Rijeka, 51000 Rijeka, Croatia.ORCID 0000-0001-5744-6677
Marina N KarpenkoPavlov Department of Physiology, Institute of Experimental Medicine, 197376 Saint Petersburg, Russia.
Victoria A MaistrenkoPavlov Department of Physiology, Institute of Experimental Medicine, 197376 Saint Petersburg, Russia.ORCID 0000-0001-7004-7873
Svetlana S LazukoDepartment of Physiology, Vitebsk State Medical University, Frunze Av. 27, 210023 Vitebsk, Belarus.
Lyudmila E BelyevaDepartment of Pathophysiology, Vitebsk State Medical University, Frunze Av. 27, 210023 Vitebsk, Belarus.
Mustapha KamelResearch, Educational and Innovative Center of Chemical and Pharmaceutical Technologies Chemical Technology Institute, Ural Federal University Named after the First President of Russia B. N. Yeltsin, 620002 Ekaterinburg, Russia.
Alexey V BuhlerResearch, Educational and Innovative Center of Chemical and Pharmaceutical Technologies Chemical Technology Institute, Ural Federal University Named after the First President of Russia B. N. Yeltsin, 620002 Ekaterinburg, Russia.
Elena G KovalevaResearch, Educational and Innovative Center of Chemical and Pharmaceutical Technologies Chemical Technology Institute, Ural Federal University Named after the First President of Russia B. N. Yeltsin, 620002 Ekaterinburg, Russia.
Ural Federal University · RUInstitute of Experimental Medicine · RUSouth Ural State University · RUVitebsk State Medical University · BYPavlov Institute of Physiology of the Russian Academy of Sciences · RUUniversity of Rijeka · HR

Funding

Russian Science Foundation grant RSF-Chelyabinsk Region number 23-15-20040.
6 · The paper itself

Abstract

Glucocorticoids are metabolized by the CYP3A isoform of cytochrome P450 and by 11-β-hydroxysteroid dehydrogenase type 1 (11β-HSD-1). Experimental data suggest that post-traumatic stress disorder (PTSD) is associated with an increase in hepatic 11β-HSD-1 activity and a concomitant decrease in hepatic CYP3A activity.

Indexed as

GlucocorticoidsStress Disorders, Post-Traumatic11-beta-Hydroxysteroid Dehydrogenases11-beta-Hydroxysteroid Dehydrogenase Type 1AnimalsCorticosteroneCytochrome P-450 CYP3AHumansHydroxysteroid DehydrogenasesRatsResveratrol11-beta-Hydroxysteroid Dehydrogenases11-beta-Hydroxysteroid Dehydrogenase Type 1CorticosteroneCytochrome P-450 CYP3AGlucocorticoidsHydroxysteroid DehydrogenasesResveratrol11-β-hydroxysteroid dehydrogenase type 1anxietyCYP3Aglucocorticoidsmolecular dynamicsPTSDtrans-resveratrol

Identifiers

PMID37298287
PMCPMC10253377
OpenAlexW4378573866

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.