Evidence map›Paper›PMID 37298283›Full record

ArticleInternational journal of molecular sciences2023

Investigation of Flavonoid Scaffolds as DAX1 Inhibitors against Ewing Sarcoma through Pharmacoinformatic and Dynamic Simulation Studies.

Muhammad Yasir, Jinyoung Park, Eun-Taek Han, Won Sun Park, Jin-Hee Han, Yong-Soo Kwon, Hee-Jae Lee, Mubashir Hassan, Andrzej Kloczkowski, Wanjoo Chun

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 14 citations in OpenAlex.

  1. Targeted and molecular therapies in Ewing sarcoma: a comprehensive review of preclinical and clinical advances.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026
    Review
  2. Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Unlocking epigenetics for precision treatment of Ewing's sarcoma.Chinese journal of cancer research = Chung-kuo yen cheng yen chiu · 2024
    Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Muhammad YasirDepartment of Pharmacology, Kangwon National University School of Medicine, Chuncheon 24341, Republic of Korea.
Jinyoung ParkDepartment of Pharmacology, Kangwon National University School of Medicine, Chuncheon 24341, Republic of Korea.
Eun-Taek HanDepartment of Medical Environmental Biology and Tropical Medicine, Kangwon National University School of Medicine, Chuncheon 24341, Republic of Korea.
Won Sun ParkDepartment of Physiology, Kangwon National University School of Medicine, Chuncheon 24341, Republic of Korea.
Jin-Hee HanDepartment of Medical Environmental Biology and Tropical Medicine, Kangwon National University School of Medicine, Chuncheon 24341, Republic of Korea.ORCID 0000-0003-0836-6675
Yong-Soo KwonCollege of Pharmacy, Kangwon National University School of Medicine, Chuncheon 24341, Republic of Korea.
Hee-Jae LeeDepartment of Pharmacology, Kangwon National University School of Medicine, Chuncheon 24341, Republic of Korea.
Mubashir HassanThe Steve and Cindy Rasmussen Institute for Genomic Medicine at Nationwide Children's Hospital, Columbus, OH 43205, USA.
Andrzej KloczkowskiThe Steve and Cindy Rasmussen Institute for Genomic Medicine at Nationwide Children's Hospital, Columbus, OH 43205, USA.ORCID 0000-0003-1002-5095
Wanjoo ChunDepartment of Pharmacology, Kangwon National University School of Medicine, Chuncheon 24341, Republic of Korea.ORCID 0000-0003-1984-3545
Kangwon National University · KRNationwide Children's Hospital · US

Funding

Novel Use of Genome Information to Understand MutationsR01HG012117 · NHGRI · IOWA STATE UNIVERSITY · PI JERNIGAN, ROBERT L, KLOCZKOWSKI, ANDRZEJ · 2021 to 2025
$2.3M
Protein Sequence MatchingR01GM127701 · NIGMS · IOWA STATE UNIVERSITY · PI JERNIGAN, ROBERT L, KLOCZKOWSKI, ANDRZEJ · 2018 to 2021
$1.4M
NHGRI NIH HHS R01 HG012117NIGMS NIH HHS R01 GM127701NIH HHS R01 GM127701NIH HHS R01HG012117
6 · The paper itself

Abstract

Dosage-sensitive sex reversal, adrenal hypoplasia critical region, on chromosome X, gene 1 (DAX1) is an orphan nuclear receptor encoded by the

Indexed as

Sarcoma, EwingHumansMolecular Docking SimulationReceptors, Retinoic AcidRepressor ProteinsReceptors, Retinoic AcidRepressor ProteinsDAX1Ewing sarcomaflavonoidsmolecular dockingmolecular dynamics simulationpharmacogenomics

Identifiers

PMID37298283
PMCPMC10253386
OpenAlexW4378575566

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.