Evidence map›Paper›PMID 37298224›Full record

ReviewInternational journal of molecular sciences2023

Recent Mechanisms of Neurodegeneration and Photobiomodulation in the Context of Alzheimer's Disease.

Matthew Su, Damir Nizamutdinov, Hanli Liu, Jason H Huang

Registry-linked trialAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07224607 (A Longitudinal Study Investigating the Effects of Photobiomodulation), which is not on this map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07224607 narecruitingnot on this mapstarted 2025, after this paper: background citation

A Longitudinal Study Investigating the Effects of Photobiomodulation (PBM) on Cognitive Function and Alzheimer's Disease (AD)-Related Biomarkers in Individuals With Mild Cognitive Impairment (MCI) or Dementia Due to AD

TypeinterventionalSponsorCedars-Sinai Medical CenterRan2025 to 2026Enrolled45ConditionsAlzheimer's DiseaseArmsPhotobiomodulation
3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Review
  6. Article
  7. Review
  8. Article
  9. Photobiomodulation for Neurodegenerative Diseases: A Scoping Review.International journal of molecular sciences · 2024
    Article
  10. Review
  11. Review
  12. Article
  13. Review
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Matthew SuDepartment of BioSciences, Rice University, Houston, TX 77005, USA.
Damir NizamutdinovDepartment of Neurosurgery, College of Medicine, Texas A&M University, Temple, TX 76508, USA.
Hanli LiuDepartment of Bioengineering, The University of Texas at Arlington, Arlington, TX 76010, USA.ORCID 0000-0002-9312-5691
Jason H HuangDepartment of Neurosurgery, College of Medicine, Texas A&M University, Temple, TX 76508, USA.ORCID 0000-0002-4426-0168

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alzheimer's disease (AD) is a neurodegenerative disease and the world's primary cause of dementia, a condition characterized by significant progressive declines in memory and intellectual capacities. While dementia is the main symptom of Alzheimer's, the disease presents with many other debilitating symptoms, and currently, there is no known treatment exists to stop its irreversible progression or cure the disease. Photobiomodulation has emerged as a very promising treatment for improving brain function, using light in the range from red to the near-infrared spectrum depending on the application, tissue penetration, and density of the target area. The goal of this comprehensive review is to discuss the most recent achievements in and mechanisms of AD pathogenesis with respect to neurodegeneration. It also provides an overview of the mechanisms of photobiomodulation associated with AD pathology and the benefits of transcranial near-infrared light treatment as a potential therapeutic solution. This review also discusses the older reports and hypotheses associated with the development of AD, as well as some other approved AD drugs.

Indexed as

Alzheimer DiseaseNeurodegenerative DiseasesHumansInfrared RaysAlzheimer’s diseasemechanismsnear-infrared lightneurodegenerationphotobiomodulationtranscranial

Identifiers

PMID37298224
PMCPMC10253105

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.