Evidence map›Paper›PMID 37298217›Full record

ArticleInternational journal of molecular sciences2023

The Methylation Analysis of the

Mattia Dalle Nogare, Sarah D'Annunzio, Giovanni Vazza, Daniela Regazzo, Luna Picello, Luca Denaro, Giacomo Voltan, Carla Scaroni, Filippo Ceccato, Gianluca Occhi

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. DNA Methylation in Pituitary Adenomas: A Scoping Review.International journal of molecular sciences · 2025
    Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Mattia Dalle NogareDepartment of Biology, University of Padova, 35128 Padova, Italy.ORCID 0000-0001-9419-830X
Sarah D'AnnunzioDepartment of Cellular, Computational and Integrative Biology (CIBIO), University of Trento, 38123 Trento, Italy.
Giovanni VazzaDepartment of Biology, University of Padova, 35128 Padova, Italy.
Daniela RegazzoEndocrinology Unit, Department of Medicine, Padova University Hospital, 35121 Padova, Italy.ORCID 0000-0002-1942-7202
Luna PicelloDepartment of Biology, University of Padova, 35128 Padova, Italy.
Luca DenaroAcademic Neurosurgery, Department of Neurosciences, Padova University Hospital, 35121 Padova, Italy.ORCID 0000-0002-2529-6149
Giacomo VoltanEndocrinology Unit, Department of Medicine, Padova University Hospital, 35121 Padova, Italy.
Carla ScaroniEndocrinology Unit, Department of Medicine, Padova University Hospital, 35121 Padova, Italy.
Filippo CeccatoEndocrinology Unit, Department of Medicine, Padova University Hospital, 35121 Padova, Italy.ORCID 0000-0003-1456-8716
Gianluca OcchiDepartment of Biology, University of Padova, 35128 Padova, Italy.ORCID 0000-0003-4065-4677
University of Padua · ITUniversity of Trento · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The glucose-dependent insulinotropic polypeptide receptor (GIPR) is aberrantly expressed in about one-third of GH-secreting pituitary adenomas (GH-PAs) and has been associated with a paradoxical increase of GH after a glucose load. The reason for such an overexpression has not yet been clarified. In this work, we aimed to evaluate whether locus-specific changes in DNA methylation patterns could contribute to this phenomenon. By cloning bisulfite-sequencing PCR, we compared the methylation pattern of the GIPR locus in GIPR-positive (GIPR

Indexed as

AdenomaGrowth Hormone-Secreting Pituitary AdenomaReceptors, Gastrointestinal HormoneDecitabineDNA MethylationEpigenesis, GeneticHumansDecitabinegastric inhibitory polypeptide receptorReceptors, Gastrointestinal Hormone5-aza-2′-deoxycytidineacromegalyCpG methylationGH-secreting pituitary adenomasglucose-dependent insulinotropic polypeptide receptor (GIPR)

Identifiers

PMID37298217
PMCPMC10252571
OpenAlexW4378469528

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.