Evidence map›Paper›PMID 37298154›Full record

ArticleInternational journal of molecular sciences2023

Zn

Alessio Pelucelli, Massimiliano Peana, Bartosz Orzeł, Karolina Piasta, Elzbieta Gumienna-Kontecka, Serenella Medici, Maria Antonietta Zoroddu

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
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  4. Review
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Alessio PelucelliDepartment of Chemical, Physical, Mathematical and Natural Sciences, University of Sassari, 07100 Sassari, Italy.ORCID 0000-0002-9502-7585
Massimiliano PeanaDepartment of Chemical, Physical, Mathematical and Natural Sciences, University of Sassari, 07100 Sassari, Italy.ORCID 0000-0002-3306-0419
Bartosz OrzełFaculty of Chemistry, University of Wroclaw, 50-383 Wroclaw, Poland.
Karolina PiastaFaculty of Chemistry, University of Wroclaw, 50-383 Wroclaw, Poland.
Elzbieta Gumienna-KonteckaFaculty of Chemistry, University of Wroclaw, 50-383 Wroclaw, Poland.ORCID 0000-0002-9556-6378
Serenella MediciDepartment of Chemical, Physical, Mathematical and Natural Sciences, University of Sassari, 07100 Sassari, Italy.ORCID 0000-0002-4304-0251
Maria Antonietta ZorodduDepartment of Chemical, Physical, Mathematical and Natural Sciences, University of Sassari, 07100 Sassari, Italy.ORCID 0000-0001-9583-4750
University of Sassari · ITUniversity of Wrocław · PL

Funding

Fondo di Ateneo per la ricerca 2019, FAR 2019 UNISS Rep. 2467, Prot. 94737 07/08/2019Fondo di Ateneo per la ricerca 2020, FAR 2020 UNISS Rep. 2465, Prot. 0097985 01/09/2020UA2002DOTTRIC2021 articolo 9, comma 3, D.M. 8 febbraio 2013, n. 45
6 · The paper itself

Abstract

The spike protein (S) of SARS-CoV-2 is able to bind to the human angiotensin-converting enzyme 2 (ACE2) receptor with a much higher affinity compared to other coronaviruses. The binding interface between the ACE2 receptor and the spike protein plays a critical role in the entry mechanism of the SARS-CoV-2 virus. There are specific amino acids involved in the interaction between the S protein and the ACE2 receptor. This specificity is critical for the virus to establish a systemic infection and cause COVID-19 disease. In the ACE2 receptor, the largest number of amino acids playing a crucial role in the mechanism of interaction and recognition with the S protein is located in the C-terminal part, which represents the main binding region between ACE2 and S. This fragment is abundant in coordination residues such as aspartates, glutamates, and histidine that could be targeted by metal ions. Zn

Indexed as

COVID-19Amino AcidsAngiotensin-Converting Enzyme 2Binding SitesHumansProtein BindingSARS-CoV-2Spike Glycoprotein, CoronavirusZincAmino AcidsAngiotensin-Converting Enzyme 2Spike Glycoprotein, Coronavirusspike protein, SARS-CoV-2ZincACE2copper complexesmetal interactionNMRpeptidespotentiometryspectroscopyzinc complexes

Identifiers

PMID37298154
PMCPMC10252707
OpenAlexW4378228033

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.