Evidence map›Paper›PMID 37297922›Full record

ArticleJournal of clinical medicine2023

Nailfold Videocapillaroscopic Alterations as Markers of Microangiopathy in COVID-19 Patients.

Roberta Gualtierotti, Sharon E Fox, Fernanda Da Silva Lameira, Andrea Giachi, Luca Valenti, Maria Orietta Borghi, Pier Luigi Meroni, Massimo Cugno, Flora Peyvandi, On Behalf Of The Capcovid Study Group

Open access · goldAbstract read
In one paragraph

Article in Journal of clinical medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. A Window into the Vascular Endothelium in Covid-19: Nails.Dermatology practical & conceptual · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Roberta GualtierottiS.C. Medicina-Emostasi e Trombosi, Centro Emofilia e Trombosi Angelo Bianchi Bonomi, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico di Milano, 20122 Milan, Italy.ORCID 0000-0001-6465-7624
Sharon E FoxDepartment of Pathology, Louisiana State University Health Sciences Center, New Orleans, LA 70802, USA.ORCID 0000-0002-0766-5393
Fernanda Da Silva LameiraDepartment of Pathology, Louisiana State University Health Sciences Center, New Orleans, LA 70802, USA.
Andrea GiachiS.C. Medicina-Emostasi e Trombosi, Centro Emofilia e Trombosi Angelo Bianchi Bonomi, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico di Milano, 20122 Milan, Italy.ORCID 0000-0002-8798-0552
Luca ValentiDepartment of Pathophysiology and Transplantation, Università Degli Studi di Milano, 20122 Milan, Italy.
Maria Orietta BorghiDepartment of Clinical Sciences and Community Health, Università Degli Studi di Milano, 20122 Milan, Italy.ORCID 0000-0001-8967-9678
Pier Luigi MeroniImmunorheumatology Research Laboratory, IRCCS Istituto Auxologico Italiano, 20095 Milan, Italy.ORCID 0000-0002-3394-1451
Massimo CugnoS.C. Medicina-Emostasi e Trombosi, Centro Emofilia e Trombosi Angelo Bianchi Bonomi, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico di Milano, 20122 Milan, Italy.ORCID 0000-0002-9918-0763
Flora PeyvandiS.C. Medicina-Emostasi e Trombosi, Centro Emofilia e Trombosi Angelo Bianchi Bonomi, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico di Milano, 20122 Milan, Italy.ORCID 0000-0001-7423-9864
On Behalf Of The Capcovid Study Group
University of Milan · ITIRCCS Istituto Auxologico Italiano · ITLouisiana State University Health Sciences Center New Orleans · USSoutheast Louisiana Veterans Health Care System · US

Funding

European League Against Rheumatism Q422PV55Ministero della Salute RC2022
6 · The paper itself

Abstract

Nailfold videocapillaroscopic alterations have been described in COVID-19, but their correlations with biomarkers of inflammation, coagulation and endothelial perturbation are still unclear, and no information is available on nailfold histopathology. Nailfold videocapillaroscopy was performed on fifteen patients with COVID-19 in Milan, Italy and the signs of microangiopathy were correlated with plasma biomarkers of inflammation (C reactive protein [CRP], ferritin), coagulation (D-dimer, fibrinogen), endothelial perturbation (Von Willebrand factor [VWF]) and angiogenesis (vascular endothelial growth factor [VEGF]) along with genetic drivers of COVID-19 susceptibility. Histopathological analysis of autoptic nailfold excisions was performed on fifteen patients who died for COVID-19 in New Orleans, United States. All COVID-19 patients studied with videocapillaroscopy showed alterations rarely seen in healthy individuals consistent with microangiopathy, such as hemosiderin deposits (sign of microthrombosis and microhemorrhages) and enlarged loops (sign of endotheliopathy). The number of hemosiderin deposits correlated both with ferritin and CRP levels (r = 0.67,

Indexed as

COVID-19endothelial perturbationhemosiderinnailfold videocapillaroscopyVon Willebrand factor

Identifiers

PMID37297922
PMCPMC10253962
OpenAlexW4378619160

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.