Evidence map›Paper›PMID 37297920›Full record

ArticleJournal of clinical medicine2023

Predictive Value of Total Metabolic Tumor Burden Prior to Treatment in NSCLC Patients Treated with Immune Checkpoint Inhibition.

Ken Kudura, Nando Ritz, Arnoud J Templeton, Tim Kutzker, Robert Foerster, Kwadwo Antwi, Michael C Kreissl, Martin H K Hoffmann

Abstract read
In one paragraph

Article in Journal of clinical medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. The role of baselineTherapeutic advances in medical oncology · 2024
    Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ken KuduraDepartment of Nuclear Medicine, Sankt Clara Hospital, 4058 Basel, Switzerland.
Nando RitzFaculty of Medicine, University of Basel, 4001 Basel, Switzerland.
Arnoud J TempletonSankt Clara Research, 4002 Basel, Switzerland.
Tim KutzkerFaculty of Applied Statistics, Humboldt University, 10117 Berlin, Germany.
Robert FoersterDepartment of Radiooncology, Cantonal Hospital Winterthur, 8400 Winterthur, Switzerland.ORCID 0000-0002-7664-9207
Kwadwo AntwiDepartment of Nuclear Medicine, Sankt Clara Hospital, 4058 Basel, Switzerland.
Michael C KreisslDivision of Nuclear Medicine, Department of Radiology and Nuclear Medicine, University Hospital Magdeburg, 39120 Magdeburg, Germany.ORCID 0000-0001-5905-6015
Martin H K HoffmannDepartment of Nuclear Medicine, Sankt Clara Hospital, 4058 Basel, Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesWe aimed to assess the predictive value of the total metabolic tumor burden prior to treatment in patients with advanced non-small-cell lung cancer (NSCLC) receiving immune checkpoint inhibitors (ICIs).

methodsPre-treatment 2-deoxy-2-[

resultsA total of 125 NSCLC patients were included. Osseous metastases were the most frequent distant metastases (n = 17), followed by thoracal distant metastases (pulmonal = 14 and pleural = 13). Total metabolic tumor burden prior to treatment was significantly higher in patients treated with ICIs (mean

conclusionsMorphological and metabolic properties of the primary tumors prior to treatment in advanced NSCLC patients treated with ICI showed great outcome prediction performances, as opposed to the pre-treatment total metabolic tumor burdens, captured by

Indexed as

FDG-PET/CTimmunotherapylung cancermetabolic tumor burdennovel therapeutic approachesNSCLCpredictive biomarker

Identifiers

PMID37297920
PMCPMC10253507

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.