Evidence map›Paper›PMID 37297869›Full record

ArticleJournal of clinical medicine2023

Barotrauma during Noninvasive Respiratory Support in COVID-19 Pneumonia Outside ICU: The Ancillary COVIMIX-2 Study.

Luigi Vetrugno, Cristian Deana, Nadia Castaldo, Alberto Fantin, Alessandro Belletti, Emanuela Sozio, Maria De Martino, Miriam Isola, Diego Palumbo, Federico Longhini and 7 more

Open access · goldAbstract read
In one paragraph

Article in Journal of clinical medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 6 institutions in 1 country.

Luigi VetrugnoDepartment of Medical, Oral and Biotechnological Sciences, University of Chieti-Pescara, 66100 Chieti, Italy.ORCID 0000-0003-3745-8368
Cristian DeanaDepartment of Anesthesia and Intensive Care, Health Integrated Agency of Friuli Venezia Giulia, Piazzale Santa Maria della Misericordia 15, 33100 Udine, Italy.ORCID 0000-0002-1626-3177
Nadia CastaldoPulmonology Unit, Department of Cardio-Thoracic Surgery, Health Integrated Agency of Friuli Venezia Giulia, 33100 Udine, Italy.ORCID 0000-0003-4660-0450
Alberto FantinPulmonology Unit, Department of Cardio-Thoracic Surgery, Health Integrated Agency of Friuli Venezia Giulia, 33100 Udine, Italy.ORCID 0000-0002-5707-775X
Alessandro BellettiDepartment of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.ORCID 0000-0003-3131-0565
Emanuela SozioInfectious Disease Unit, Health Integrated Agency of Friuli Venezia Giulia, 33100 Udine, Italy.ORCID 0000-0001-6247-5958
Maria De MartinoDepartment of Medical Area, University of Udine, 33100 Udine, Italy.ORCID 0000-0002-0445-9578
Miriam IsolaDepartment of Medical Area, University of Udine, 33100 Udine, Italy.ORCID 0000-0002-6391-1720
Diego PalumboDepartment of Radiology, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.ORCID 0000-0002-7906-540X
Federico LonghiniAnesthesia and Intensive Care Unit, Department of Medical and Surgical Sciences, University Hospital Mater, Domini, Magna Graecia University, 88100 Catanzaro, Italy.ORCID 0000-0002-6970-7202
Gianmaria CammarotaAnesthesiology and Intensive Care, Department of Translational medicine, Faculty of Medicine and Surgery, University of Ferrara, 44121 Ferrara, Italy.
Savino SpadaroDepartment of Medicine and Surgery, University of Perugia, 06123 Perugia, Italy.ORCID 0000-0001-5027-5318
Salvatore Maurizio MaggioreDepartment of Anesthesiology, Critical Care Medicine and Emergency, SS. Annunziata Hospital, 66100 Chieti, Italy.ORCID 0000-0002-1828-9143
Flavio BassiDepartment of Anesthesia and Intensive Care, Health Integrated Agency of Friuli Venezia Giulia, Piazzale Santa Maria della Misericordia 15, 33100 Udine, Italy.
Carlo TasciniInfectious Disease Unit, Health Integrated Agency of Friuli Venezia Giulia, 33100 Udine, Italy.
Vincenzo PatrunoPulmonology Unit, Department of Cardio-Thoracic Surgery, Health Integrated Agency of Friuli Venezia Giulia, 33100 Udine, Italy.
Covimix-Study Group
University of Udine · ITUniversity of Chieti-Pescara · ITVita-Salute San Raffaele University · ITMagna Graecia University · ITUniversity of Ferrara · ITUniversity of Perugia · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundNoninvasive respiratory support (NIRS) has been extensively used during the COVID-19 surge for patients with acute respiratory failure. However, little data are available about barotrauma during NIRS in patients treated outside the intensive care unit (ICU) setting.

methodsCOVIMIX-2 was an ancillary analysis of the previous COVIMIX study, a large multicenter observational work investigating the frequencies of barotrauma (i.e., pneumothorax and pneumomediastinum) in adult patients with COVID-19 interstitial pneumonia. Only patients treated with NIRS outside the ICU were considered. Baseline characteristics, clinical and radiological disease severity, type of ventilatory support used, blood tests and mortality were recorded.

resultsIn all, 179 patients were included, 60 of them with barotrauma. They were older and had lower BMI than controls (

conclusionsCOVIMIX-2 showed a low frequency for barotrauma, around 0.3%. The type of NIRS used seems not to increase this risk. Patients with barotrauma were older, with more severe systemic disease, and showed increased mortality.

Indexed as

acute respiratory failurebarotraumaCOVID-19high flow nasal oxygennoninvasive ventilationpneumothorax

Identifiers

PMID37297869
PMCPMC10253529
OpenAlexW4378468956

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.