ReviewMaterials (Basel, Switzerland)2023
Calcium Phosphate Cements as Carriers of Functional Substances for the Treatment of Bone Tissue.
Review in Materials (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 23 citations in OpenAlex.
- Amine-linked heteroporous covalent organic framework for synergistic anti-infective therapy of post-traumatic osteomyelitis.Nature communications · 2026Article
- Calcium Phosphate Nanostructured Biocomposites with Applications in Bone Tissue Engineering.Materials (Basel, Switzerland) · 2026Review
- Percutaneous calcium phosphate cement injection for unicameral bone cysts: mid- to long-term clinical and radiographic outcomes.Frontiers in surgery · 2026Article
- Synergistic effects of bioactive glass and sodium alginate on the surface properties and therapeutic release of ciprofloxacin from apatite cements.International journal of pharmaceutics: X · 2025Article
- Clinically applicable antibiotic modification of ready-to-use calcium phosphate cement pastes.Journal of orthopaedic surgery and research · 2025Article
- Application of an innovative isoniazid-loaded biomimetic mineralized bone collagen scaffold in bone defect treatment.RSC advances · 2025Article
- Pure and Doped Brushite Cements Loaded with Piroxicam for Prolonged and Constant Drug Release.Materials (Basel, Switzerland) · 2025Article
- Polydopamine-functionalized calcium-deficient hydroxyapatite 3D-printed scaffold with sustained doxorubicin release for synergistic chemo-photothermal therapy of osteosarcoma and accelerated bone regeneration.Materials today. Bio · 2024Article
- Personalized bioceramic grafts for craniomaxillofacial bone regeneration.International journal of oral science · 2024Review
- Cu-doped calcium phosphate supraparticles for bone tissue regeneration.RSC advances · 2024Article
- Titanium Dioxide Promotes the Growth and Aggregation of Calcium Phosphate and Monosodium Urate Mixed Crystals.Crystals · 2024Article
- Materials in the NaMaterials (Basel, Switzerland) · 2023Review
- Mechanical Properties and Liquid Absorption of Calcium Phosphate Composite Cements.Materials (Basel, Switzerland) · 2023Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Interest in calcium phosphate cements as materials for the restoration and treatment of bone tissue defects is still high. Despite commercialization and use in the clinic, the calcium phosphate cements have great potential for development. Existing approaches to the production of calcium phosphate cements as drugs are analyzed. A description of the pathogenesis of the main diseases of bone tissue (trauma, osteomyelitis, osteoporosis and tumor) and effective common treatment strategies are presented in the review. An analysis of the modern understanding of the complex action of the cement matrix and the additives and drugs distributed in it in relation to the successful treatment of bone defects is given. The mechanisms of biological action of functional substances determine the effectiveness of use in certain clinical cases. An important direction of using calcium phosphate cements as a carrier of functional substances is the volumetric incorporation of anti-inflammatory, antitumor, antiresorptive and osteogenic functional substances. The main functionalization requirement for carrier materials is prolonged elution. Various release factors related to the matrix, functional substances and elution conditions are considered in the work. It is shown that cements are a complex system. Changing one of the many initial parameters in a wide range changes the final characteristics of the matrix and, accordingly, the kinetics. The main approaches to the effective functionalization of calcium phosphate cements are considered in the review.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.