Evidence map›Paper›PMID 37297029›Full record

ArticleMaterials (Basel, Switzerland)2023

Antibacterial 3D-Printed Silver Nanoparticle/Poly Lactic-Co-Glycolic Acid (PLGA) Scaffolds for Bone Tissue Engineering.

Fajun Chen, Jian Han, Zeyong Guo, Chongjing Mu, Chuandi Yu, Zhibo Ji, Lei Sun, Yujuan Wang, Junfeng Wang

Open access · goldAbstract read
In one paragraph

Article in Materials (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
5.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 46 citations in OpenAlex.

  1. Article
  2. Review
  3. Application of PLCL as a biodegradable polymer in biomedical engineering.Journal of materials science. Materials in medicine · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 1 country.

Fajun ChenDepartment of Anatomy, School of Basic Medicine, Anhui Medical University, No.81, Meishan Road, Shushan District, Hefei 230032, China.
Jian HanHigh Magnetic Field Laboratory, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Science Island, Hefei 230031, China.
Zeyong GuoHigh Magnetic Field Laboratory, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Science Island, Hefei 230031, China.
Chongjing MuThe Affiliated Suzhou Hospital of Nanjing Medical University, 16 Baita West Road, Suzhou 215000, China.
Chuandi YuHigh Magnetic Field Laboratory, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Science Island, Hefei 230031, China.
Zhibo JiDepartment of Stomatology, The Second Affiliated Hospital of Anhui Medical University, Hefei 230601, China.
Lei SunDepartment of Stomatology, The Second Affiliated Hospital of Anhui Medical University, Hefei 230601, China.
Yujuan WangHigh Magnetic Field Laboratory, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Science Island, Hefei 230031, China.ORCID 0000-0003-2648-0850
Junfeng WangDepartment of Anatomy, School of Basic Medicine, Anhui Medical University, No.81, Meishan Road, Shushan District, Hefei 230032, China.ORCID 0000-0002-9608-6851
Anhui Medical University · CNUniversity of Science and Technology of China · CNChinese Academy of Sciences · CNShanghai Jiao Tong University · CNSuzhou Municipal Hospital · CN

Funding

the grants from the Hefei Institutes of Physical Science Director's Fund No. YZJJZX202014USTC Innovation and Entrepreneurship Fund for Graduate Students No. WK5290000003
6 · The paper itself

Abstract

Infectious bone defects present a major challenge in the clinical setting currently. In order to address this issue, it is imperative to explore the development of bone tissue engineering scaffolds that are equipped with both antibacterial and bone regenerative capabilities. In this study, we fabricated antibacterial scaffolds using a silver nanoparticle/poly lactic-co-glycolic acid (AgNP/PLGA) material via a direct ink writing (DIW) 3D printing technique. The scaffolds' microstructure, mechanical properties, and biological attributes were rigorously assessed to determine their fitness for repairing bone defects. The surface pores of the AgNPs/PLGA scaffolds were uniform, and the AgNPs were evenly distributed within the scaffolds, as confirmed via scanning electron microscopy (SEM). Tensile testing confirmed that the addition of AgNPs enhanced the mechanical strength of the scaffolds. The release curves of the silver ions confirmed that the AgNPs/PLGA scaffolds released them continuously after an initial burst. The growth of hydroxyapatite (HAP) was characterized via SEM and X-ray diffraction (XRD). The results showed that HAP was deposited on the scaffolds, and also confirmed that the scaffolds had mixed with the AgNPs. All scaffolds containing AgNPs exhibited antibacterial properties against

Indexed as

3D printingAgNPsantibacterial scaffoldbone tissue engineeringPLGA

Identifiers

PMID37297029
PMCPMC10253518
OpenAlexW4378085495

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.