Evidence map›Paper›PMID 37297023›Full record

ArticleCancers2023

deepPERFECT: Novel Deep Learning CT Synthesis Method for Expeditious Pancreatic Cancer Radiotherapy.

Hamed Hooshangnejad, Quan Chen, Xue Feng, Rui Zhang, Kai Ding

Abstract read
In one paragraph

Article in Cancers, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Artificial intelligence in pancreatic cancer: applications in early detection, tumor staging, and survival prediction-a comprehensive review.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026
    Review
  2. Deep Learning for CT Synthesis in Radiotherapy.Bioengineering (Basel, Switzerland) · 2025
    Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Hamed HooshangnejadDepartment of Biomedical Engineering, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA.ORCID 0000-0002-1953-0568
Quan ChenCity of Hope Comprehensive Cancer Center, Duarte, CA 91010, USA.
Xue FengCarina Medical LLC, Lexington, KY 40513, USA.ORCID 0000-0002-2181-9889
Rui ZhangDivision of Computational Health Sciences, Department of Surgery, University of Minnesota, Minneapolis, MN 55455, USA.
Kai DingDepartment of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA.ORCID 0000-0002-8202-0173

Funding

Spacer Enabled Robust Radiation Therapy (SERRT)R37CA229417 · NCI · JOHNS HOPKINS UNIVERSITY · PI DING, KAI · 2018 to 2021
$1.5M
NCI NIH HHS R37 CA229417NIH HHS R37CA229417
6 · The paper itself

Abstract

Major sources of delay in the standard of care RT workflow are the need for multiple appointments and separate image acquisition. In this work, we addressed the question of how we can expedite the workflow by synthesizing planning CT from diagnostic CT. This idea is based on the theory that diagnostic CT can be used for RT planning, but in practice, due to the differences in patient setup and acquisition techniques, separate planning CT is required. We developed a generative deep learning model, deepPERFECT, that is trained to capture these differences and generate deformation vector fields to transform diagnostic CT into preliminary planning CT. We performed detailed analysis both from an image quality and a dosimetric point of view, and showed that deepPERFECT enabled the preliminary RT planning to be used for preliminary and early plan dosimetric assessment and evaluation.

Indexed as

CT synthesisdeep learningdeepPERFECTexpeditious radiotherapypancreatic cancertime to treatment initiation

Identifiers

PMID37297023
PMCPMC10252954

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.