Evidence map›Paper›PMID 37296998›Full record

ArticleCancers2023

Creation of EGD-Derived Gastric Cancer Organoids to Predict Treatment Responses.

Hannah G McDonald, Megan M Harper, Kristen Hill, Anqi Gao, Angelica L Solomon, Charles J Bailey, Miranda Lin, Mautin Barry-Hundeyin, Michael J Cavnar, Samuel H Mardini and 9 more

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.9field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 2 institutions in 2 countries.

Hannah G McDonaldDivision of Surgical Oncology, Department of General Surgery, University of Kentucky, Lexington, KY 40536, USA.ORCID 0000-0002-4523-907X
Megan M HarperDivision of Surgical Oncology, Department of General Surgery, University of Kentucky, Lexington, KY 40536, USA.ORCID 0000-0002-2935-6292
Kristen HillCollege of Pharmacy, University of Kentucky, Lexington, KY 40536, USA.ORCID 0000-0003-3757-2822
Anqi GaoDivision of Surgical Oncology, Department of General Surgery, University of Kentucky, Lexington, KY 40536, USA.
Angelica L SolomonDivision of Surgical Oncology, Department of General Surgery, University of Kentucky, Lexington, KY 40536, USA.ORCID 0009-0004-8463-3960
Charles J BaileyDivision of Surgical Oncology, Department of General Surgery, University of Kentucky, Lexington, KY 40536, USA.
Miranda LinDivision of Surgical Oncology, Department of General Surgery, University of Kentucky, Lexington, KY 40536, USA.ORCID 0000-0002-1250-1254
Mautin Barry-HundeyinDivision of Surgical Oncology, Department of General Surgery, University of Kentucky, Lexington, KY 40536, USA.
Michael J CavnarDivision of Surgical Oncology, Department of General Surgery, University of Kentucky, Lexington, KY 40536, USA.
Samuel H MardiniDivision of Gastroenterology, Department of Internal Medicine, University of Kentucky, Lexington, KY 40536, USA.
Prakash J PandalaiDivision of Surgical Oncology, Department of General Surgery, University of Kentucky, Lexington, KY 40536, USA.
Reema A PatelDivision of Medical Oncology, Department of Internal Medicine, University of Kentucky, Lexington, KY 40536, USA.
Jill M KolesarCollege of Pharmacy, University of Kentucky, Lexington, KY 40536, USA.ORCID 0000-0003-1802-6439
Justin A RueckertDepartment of Pathology and Laboratory Medicine, University of Kentucky, Lexington, KY 40536, USA.
Lawrence HookeyDivision of Gastroenterology, Department of Internal Medicine, Queen's University, Kingston, ON K7L 3N6, Canada.
Mark RopeleskiDivision of Gastroenterology, Department of Internal Medicine, Queen's University, Kingston, ON K7L 3N6, Canada.
Shaila J MerchantDivision of General Surgery and Surgical Oncology, Queen's University, Kingston, ON K7L 3N6, Canada.ORCID 0000-0002-8133-7988
Joseph KimDivision of Surgical Oncology, Department of General Surgery, University of Kentucky, Lexington, KY 40536, USA.ORCID 0000-0001-6313-1516
Mei GaoDivision of Surgical Oncology, Department of General Surgery, University of Kentucky, Lexington, KY 40536, USA.
University of Kentucky · USQueen's University · CA

Funding

Institutional Career Development CoreKL2TR001996 · NCATS · UNIVERSITY OF KENTUCKY · PI BUSH, MATTHEW LEE, KELLY, THOMAS H. · 2016 to 2025
$7.1M
Oncology Research Training for Surgeon-ScientistsT32CA160003 · NCI · UNIVERSITY OF KENTUCKY · PI Bernard Mark Evers, Pamela Carmen Hull · 2011 to 2026
$3.2M
NCATS NIH HHS KL2 TR001996NCI NIH HHS T32 CA160003
6 · The paper itself

Abstract

Gastric adenocarcinoma (GAd) is the third leading cause of cancer-related deaths worldwide. Most patients require perioperative chemotherapy, yet methods to accurately predict responses to therapy are lacking. Thus, patients may be unnecessarily exposed to considerable toxicities. Here, we present a novel methodology using patient-derived organoids (PDOs) that rapidly and accurately predicts the chemotherapy efficacy for GAd patients.

Indexed as

chemoresistancegastric cancerorganoids

Identifiers

PMID37296998
PMCPMC10252567
OpenAlexW4379230326

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.