Evidence map›Paper›PMID 37296925›Full record

ArticleCancers2023

Belantamab Mafodotin in Patients with Relapsed/Refractory Multiple Myeloma: Results of the Compassionate Use or the Expanded Access Program in Spain.

Javier de la Rubia, Rafael Alonso, María Esther Clavero, Elham Askari, Alfonso García, Cristina Antón, Margarita Fernández, Fernando Escalante, Ana García, Rafael Rios-Tamayo and 9 more

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 2 pooled it
5.5field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 2 syntheses or guidelines pooled it, 19 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trends in compassionate use of medicinal products: Israel 2020-2024.Israel journal of health policy research · 2025
    Article
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  7. Michael Acceptors as Anti-Cancer Compounds: Coincidence or Causality?International journal of molecular sciences · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 18 institutions in 1 country.

Javier de la RubiaHospital Universitario y Politécnico La Fe & Universidad Católica de Valencia, Centro de Investigación Biomédica en Red de Cáncer, CIBERONC CB16/12/00284, Instituto de Salud Carlos III, 28029 Madrid, Spain.ORCID 0000-0002-8354-768X
Rafael AlonsoHospital 12 de Octubre, 28041 Madrid, Spain.
María Esther ClaveroHospital Virgen de las Nieves, 18014 Granada, Spain.
Elham AskariFundación Jiménez Díaz, 28040 Madrid, Spain.
Alfonso GarcíaHospital Clínico, 47003 Valladolid, Spain.ORCID 0009-0009-4470-4652
Cristina AntónHospital Morales Meseguer, 30008 Murcia, Spain.
Margarita FernándezHospital Reina Sofía, 14004 Córdoba, Spain.ORCID 0000-0002-6819-4177
Fernando EscalanteHospital de León, 24071 León, Spain.ORCID 0000-0003-4501-9066
Ana GarcíaHospital Dr. Peset, 46017 Valencia, Spain.
Rafael Rios-TamayoHospital Puerta de Hierro, 28222 Madrid, Spain.ORCID 0000-0001-8193-1402
Venancio ConesaHospital General de Elche, 03203 Alicante, Spain.ORCID 0000-0002-6412-3419
María Arancha BermúdezHospital Marqués de Valdecilla, 39008 Santander, Spain.
Beatriz MerchánHospital Universitario de Guadalajara, 19002 Guadalajara, Spain.
Alberto E VelascoHospital Rey Juan Carlos, Móstoles, 28933 Madrid, Spain.
María Jesús BlanchardHospital Ramón y Cajal, 28034 Madrid, Spain.
Antonia SampolHospital Son Espases, 07020 Palma de Mallorca, Spain.ORCID 0000-0001-7465-6203
Eukene GainzaHospital de Galdakao, 48960 Bilbao, Spain.
Prisma Montserrat HernándezHospital de S. Pedro, 26006 Logroño, Spain.
Adrián AlegreSpain for the Spanish Myeloma Group, Hospital Universitario La Princesa, 28006 Madrid, Spain.ORCID 0000-0002-2423-822X
Hospital Universitario Doctor Peset · ESHospital de Galdakao · ESHospital de León · ESHospital General Universitario de Elche · ESHospital General Universitario Morales Meseguer · ESHospital San Pedro · ESHospital Universitario de Guadalajara · ESHospital Universitario de La Princesa · ESHospital Universitario Fundación Jiménez Díaz · ESHospital Universitario Puerta de Hierro Majadahonda · ESHospital Universitario Ramón y Cajal · ESHospital Universitario Reina Sofía · ESHospital Universitario Rey Juan Carlos · ESHospital Universitario Son Espases · ESHospital Universitario Virgen de las Nieves · ESInstituto de Salud Carlos III · ESMarqués de Valdecilla University Hospital · ESResearch Institute Hospital 12 de Octubre · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Belantamab-mafodotin (belamaf) is a novel antibody-drug conjugate targeting B-cell maturation antigen that showed anti-myeloma activity in patients with relapsed and refractory multiple myeloma (RRMM). We performed an observational, retrospective, and multicenter study aimed to assess the efficacy and safety of single-agent belamaf in 156 Spanish patients with RRMM. The median number of prior therapy lines was 5 (range, 1-10), and 88% of patients were triple-class refractory. Median follow-up was 10.9 months (range, 1-28.6). The overall response rate was 41.8% (≥CR 13.5%, VGPR 9%, PR 17.3%, MR 2%). The median progression-free survival was 3.61 months (95% CI, 2.1-5.1) and 14.47 months (95% CI, 7.91-21.04) in patients achieving at least MR (

Indexed as

belantamab mafodotinmultiple myelomarefractoryrelapsetreatment

Identifiers

PMID37296925
PMCPMC10251953
OpenAlexW4378650425

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.