Evidence map›Paper›PMID 37296889›Full record

ArticleCancers2023

Early Prediction of Response Focused on Tumor Markers in Atezolizumab plus Bevacizumab Therapy for Hepatocellular Carcinoma.

Norikazu Tanabe, Issei Saeki, Yuki Aibe, Takashi Matsuda, Tadasuke Hanazono, Maiko Nishi, Isao Hidaka, Shinya Kuwashiro, Shogo Shiratsuki, Keiji Matsuura and 12 more

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 2 institutions in 1 country.

Norikazu TanabeDivision of Laboratory, Yamaguchi University Hospital, Ube 755-8505, Yamaguchi, Japan.ORCID 0009-0005-9502-8886
Issei SaekiDepartment of Gastroenterology and Hepatology, Yamaguchi University Graduate School of Medicine, Ube 755-8505, Yamaguchi, Japan.ORCID 0000-0001-5885-5042
Yuki AibeYamaguchi Clinical Research Group-Hepatology (YCR-H), Ube 755-8505, Yamaguchi, Japan.
Takashi MatsudaYamaguchi Clinical Research Group-Hepatology (YCR-H), Ube 755-8505, Yamaguchi, Japan.
Tadasuke HanazonoYamaguchi Clinical Research Group-Hepatology (YCR-H), Ube 755-8505, Yamaguchi, Japan.
Maiko NishiYamaguchi Clinical Research Group-Hepatology (YCR-H), Ube 755-8505, Yamaguchi, Japan.
Isao HidakaYamaguchi Clinical Research Group-Hepatology (YCR-H), Ube 755-8505, Yamaguchi, Japan.
Shinya KuwashiroYamaguchi Clinical Research Group-Hepatology (YCR-H), Ube 755-8505, Yamaguchi, Japan.
Shogo ShiratsukiYamaguchi Clinical Research Group-Hepatology (YCR-H), Ube 755-8505, Yamaguchi, Japan.
Keiji MatsuuraYamaguchi Clinical Research Group-Hepatology (YCR-H), Ube 755-8505, Yamaguchi, Japan.
Maho EgusaDepartment of Gastroenterology and Hepatology, Yamaguchi University Graduate School of Medicine, Ube 755-8505, Yamaguchi, Japan.
Natsuko NishiyamaDepartment of Gastroenterology and Hepatology, Yamaguchi University Graduate School of Medicine, Ube 755-8505, Yamaguchi, Japan.
Tsuyoshi FujiokaDepartment of Gastroenterology and Hepatology, Yamaguchi University Graduate School of Medicine, Ube 755-8505, Yamaguchi, Japan.
Daiki KawamotoDepartment of Gastroenterology and Hepatology, Yamaguchi University Graduate School of Medicine, Ube 755-8505, Yamaguchi, Japan.
Ryo SasakiDepartment of Gastroenterology and Hepatology, Yamaguchi University Graduate School of Medicine, Ube 755-8505, Yamaguchi, Japan.
Tatsuro NishimuraDepartment of Gastroenterology and Hepatology, Yamaguchi University Graduate School of Medicine, Ube 755-8505, Yamaguchi, Japan.
Takashi OonoDepartment of Gastroenterology and Hepatology, Yamaguchi University Graduate School of Medicine, Ube 755-8505, Yamaguchi, Japan.
Takuro HisanagaDepartment of Gastroenterology and Hepatology, Yamaguchi University Graduate School of Medicine, Ube 755-8505, Yamaguchi, Japan.
Toshihiko MatsumotoDepartment of Gastroenterology and Hepatology, Yamaguchi University Graduate School of Medicine, Ube 755-8505, Yamaguchi, Japan.
Tsuyoshi IshikawaDepartment of Gastroenterology and Hepatology, Yamaguchi University Graduate School of Medicine, Ube 755-8505, Yamaguchi, Japan.
Takahiro YamasakiDivision of Laboratory, Yamaguchi University Hospital, Ube 755-8505, Yamaguchi, Japan.ORCID 0000-0002-9793-0399
Taro TakamiDepartment of Gastroenterology and Hepatology, Yamaguchi University Graduate School of Medicine, Ube 755-8505, Yamaguchi, Japan.ORCID 0000-0002-6689-4989
Yamaguchi University · JPTokuyama (Japan) · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Despite the promising efficacy of atezolizumab plus bevacizumab (atezo/bev), some patients with unresectable hepatocellular carcinoma (HCC) experience disease progression. This retrospective study, which included 154 patients, aimed to evaluate predictors of treatment efficacy of atezo/bev for unresectable HCC. Factors associated with treatment response were examined, focusing on tumor markers. In the high-alpha-fetoprotein (AFP) group (baseline AFP ≥ 20 ng/mL), a decrease in AFP level > 30% was an independent predictor of objective response (odds ratio, 5.517;

Indexed as

alpha-fetoproteinatezolizumabbevacizumabdes-gamma-carboxy prothrombinhepatocellular carcinomaimmune checkpoint inhibitor

Identifiers

PMID37296889
PMCPMC10251947
OpenAlexW4378528427

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.