Evidence map›Paper›PMID 37296696›Full record

ArticleDiagnostics (Basel, Switzerland)2023

A Blinded Investigation: Accentuated NK Lymphocyte CD335 (NKp46) Expression Predicts Pregnancy Failures.

Boris V Dons'koi, Serhiy M Baksheev, Irina O Sudoma, Ihor E Palyha, Ksenia G Khazhylenko, Dariia V Zabara, Yaroslava I Anoshko, Viktor E Dosenko, Evgen I Dubrovsky

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In one paragraph

Article in Diagnostics (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Boris V Dons'koiLaboratory of Immunology, Institute of Pediatrics, Obstetrics and Gynecology Named after Academician O. Lukyanova of the National Academy of Medical Sciences of Ukraine, Mayborody Str. 8, 04050 Kyiv, Ukraine.ORCID 0000-0001-9434-2826
Serhiy M Baksheev3th Maternity Hospital, 03148 Kyiv, Ukraine.
Irina O SudomaNADIYA Clinic, 03037 Kyiv, Ukraine.
Ihor E PalyhaKlinika Reproduktsiyi Lyudyny "Al'ternatyva", 79041 Lviv, Ukraine.
Ksenia G Khazhylenko"RID" Fertility Centre, 02000 Kyiv, Ukraine.
Dariia V ZabaraLaboratory of Immunology, Institute of Pediatrics, Obstetrics and Gynecology Named after Academician O. Lukyanova of the National Academy of Medical Sciences of Ukraine, Mayborody Str. 8, 04050 Kyiv, Ukraine.
Yaroslava I AnoshkoLaboratory of Immunology, Institute of Pediatrics, Obstetrics and Gynecology Named after Academician O. Lukyanova of the National Academy of Medical Sciences of Ukraine, Mayborody Str. 8, 04050 Kyiv, Ukraine.ORCID 0000-0003-1078-8244
Viktor E DosenkoDepartment of General and Molecular Pathophysiology, Bogomoletz Institute of Physiology, National Academy of Sciences of Ukraine, 02000 Kyiv, Ukraine.
Evgen I DubrovskyLaboratory of Immunology, Institute of Pediatrics, Obstetrics and Gynecology Named after Academician O. Lukyanova of the National Academy of Medical Sciences of Ukraine, Mayborody Str. 8, 04050 Kyiv, Ukraine.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimNKp46 is an NK cell receptor uniquely expressed by NK cells and a small subset of innate lymphoid cells. In our previous studies, we suggested a tight connection between the activity of NK cells and the expression of NKp46 and supported the clinical significance of NKp46 expression in NK cells in women with reproductive failures. In this study, we investigated the expression of NKp46 in NK cells in the peripheral blood of women in early pregnancy and analyzed its association with pregnancy loss.

methodsIn a blinded study, we examined blood samples and analyzed the subsequent pregnancy outcomes from 98 early pregnant women (5th-7th week of gestation-w.g.) and 66 women in the 11th-13th week of pregnancy who served as controls. We studied the expression of NKp46 and the levels of anti-cardiolipin antibodies (aCL). The results of aCL were shared with the clinic, while the expression of NKp46 was blinded and not analyzed until the end of the study.

resultsA misbalance in the NKp46

conclusionsOur results showed that accentuated levels of NKp46

Indexed as

CD335NK lymphocytesNKp46pregnancy failures

Identifiers

PMID37296696
PMCPMC10252685

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