Evidence map›Paper›PMID 37296648›Full record

ArticleCells2023

Role of Pellino-1 in Inflammation and Cardioprotection following Severe Sepsis: A Novel Mechanism in a Murine Severe Sepsis Model

Mahesh Thirunavukkarasu, Santosh Swaminathan, Andrew Kemerley, Seetur R Pradeep, Sue Ting Lim, Diego Accorsi, Rickesha Wilson, Jacob Campbell, Ibnalwalid Saad, Siu-Pok Yee and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Mahesh ThirunavukkarasuDepartment of Surgery, University of Connecticut School of Medicine, Farmington, CT 06032, USA.
Santosh SwaminathanDepartment of Surgery, University of Connecticut School of Medicine, Farmington, CT 06032, USA.
Andrew KemerleyDepartment of Surgery, University of Connecticut School of Medicine, Farmington, CT 06032, USA.
Seetur R PradeepDepartment of Surgery, University of Connecticut School of Medicine, Farmington, CT 06032, USA.ORCID 0000-0002-4423-2001
Sue Ting LimDepartment of Surgery, University of Connecticut School of Medicine, Farmington, CT 06032, USA.
Diego AccorsiDepartment of Surgery, University of Connecticut School of Medicine, Farmington, CT 06032, USA.
Rickesha WilsonDepartment of Surgery, University of Connecticut School of Medicine, Farmington, CT 06032, USA.
Jacob CampbellDepartment of Surgery, University of Connecticut School of Medicine, Farmington, CT 06032, USA.ORCID 0000-0003-2051-7819
Ibnalwalid SaadDepartment of Surgery, University of Connecticut School of Medicine, Farmington, CT 06032, USA.
Siu-Pok YeeCenter for Mouse Genome Modification, University of Connecticut Health School of Medicine, Farmington, CT 06032, USA.ORCID 0000-0002-2427-401X
J Alexander PalestyStanley J. Dudrick, Department of Surgery, Saint Mary's Hospital, Waterbury, CT 06706, USA.
David W McFaddenDepartment of Surgery, University of Connecticut School of Medicine, Farmington, CT 06032, USA.
Nilanjana MaulikDepartment of Surgery, University of Connecticut School of Medicine, Farmington, CT 06032, USA.
University of Connecticut · USUConn Health · USUniversity of Saint Mary · US

Funding

Angiogenic Regulators in Ischemic DisordersR01GM112957 · NIGMS · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI MAULIK, NILANJANA · 2015 to 2018
$1.7M
National Institutes of Health Grant (NIH) GM 112957NIGMS NIH HHS R01 GM112957
6 · The paper itself

Abstract

objectivesIntra-abdominal sepsis is commonly diagnosed in the surgical population and remains the second most common cause of sepsis overall. Sepsis-related mortality remains a significant burden in the intensive care unit despite advances in critical care. Nearly a quarter of the deaths in people with heart failure are caused by sepsis. We have observed that overexpression of mammalian Pellino-1 (Peli1), an E3 ubiquitin ligase, causes inhibition of apoptosis, oxidative stress, and preservation of cardiac function in a myocardial infarction model. Given these manifold applications, we investigated the role of Peli1 in sepsis using transgenic and knockout mouse models specific to this protein. Therefore, we aimed to explore further the myocardial dysfunction seen in sepsis through its relation to the Peli 1 protein by using the loss of function and gain-of-function strategy.

methodsA series of genetic animals were created to understand the role of Peli1 in sepsis and the preservation of heart function. Wild-type, global Peli1 knock out (Peli1

resultsAMPEL1

conclusionOur results indicate that overexpression of Peli1 is a novel approach that not only preserved cardiac function but reduced inflammatory markers and apoptosis following severe sepsis in a murine genetic model.

Indexed as

SepsisTumor Necrosis Factor-alphaAnimalsInflammationInterleukin-6MammalsMiceMyocytes, CardiacNuclear ProteinsUbiquitin-Protein LigasesInterleukin-6Nuclear ProteinsPeli1 protein, mouseTumor Necrosis Factor-alphaUbiquitin-Protein Ligasescardiac functioninfectioninflammationPeli1septic shock

Identifiers

PMID37296648
PMCPMC10252528
OpenAlexW4379054637

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.