Evidence map›Paper›PMID 37296598›Full record

ReviewCells2023

Cognitive Deficits in Aging Related to Changes in Basal Forebrain Neuronal Activity.

Irene Chaves-Coira, Nuria García-Magro, Jonathan Zegarra-Valdivia, Ignacio Torres-Alemán, Ángel Núñez

Open access · goldAbstract readReview
In one paragraph

Review in Cells, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.

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  14. Role of the Insulin-like Growth Factor System in Neurodegenerative Disease.International journal of molecular sciences · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 2 countries.

Irene Chaves-CoiraDepartment of Anatomy, Histology and Neurosciences, Universidad Autónoma de Madrid, 28029 Madrid, Spain.
Nuria García-MagroFacultad de Ciencias de la Salud, Universidad Francisco de Vitoria, Pozuelo de Alarcón, 28223 Madrid, Spain.
Jonathan Zegarra-ValdiviaAchucarro Basque Center for Neuroscience, 48940 Leioa, Spain.ORCID 0000-0003-0497-5270
Ignacio Torres-AlemánAchucarro Basque Center for Neuroscience, 48940 Leioa, Spain.ORCID 0000-0001-8107-7947
Ángel NúñezDepartment of Anatomy, Histology and Neurosciences, Universidad Autónoma de Madrid, 28029 Madrid, Spain.ORCID 0000-0002-8013-4812
Universidad Autónoma de Madrid · ESAchucarro Basque Center for Neuroscience · ESIkerbasque · ESUniversidad Francisco de Vitoria · ES

Funding

Spanish Ministerio de Ciencia e Innovación PID2019-107809RB-I00; PID2019-104376RB-I00; AEI/FEDER; MICINN
6 · The paper itself

Abstract

Aging is a physiological process accompanied by a decline in cognitive performance. The cholinergic neurons of the basal forebrain provide projections to the cortex that are directly engaged in many cognitive processes in mammals. In addition, basal forebrain neurons contribute to the generation of different rhythms in the EEG along the sleep/wakefulness cycle. The aim of this review is to provide an overview of recent advances grouped around the changes in basal forebrain activity during healthy aging. Elucidating the underlying mechanisms of brain function and their decline is especially relevant in today's society as an increasingly aged population faces higher risks of developing neurodegenerative diseases such as Alzheimer's disease. The profound age-related cognitive deficits and neurodegenerative diseases associated with basal forebrain dysfunction highlight the importance of investigating the aging of this brain region.

Indexed as

Alzheimer DiseaseBasal ForebrainAgingAnimalsCholinergic NeuronsCognitionMammalscholinergic neuronselectroencephalogramIGF-Ineurodegenerative diseasessleep

Identifiers

PMID37296598
PMCPMC10252596
OpenAlexW4378379251

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.