TCF7L1 Controls the Differentiation of Tuft Cells in Mouse Small Intestine.

Valeriya V Zinina, Melanie Sauer, Lira Nigmatullina, Nastasja Kreim, Natalia Soshnikova

Open access · goldAbstract read

In one paragraph

Article in Cells, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

0.6field-weighted citation impact, top 24% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

Tuft cells in the intestine, immunity and beyond.Nature reviews. Gastroenterology & hepatology · 2024
Review

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Valeriya V ZininaInstitute for Molecular Medicine, University Medical Center of the Johannes Gutenberg-University, 55131 Mainz, Germany.ORCID 0009-0004-7365-0108

Melanie SauerInstitute for Molecular Medicine, University Medical Center of the Johannes Gutenberg-University, 55131 Mainz, Germany.ORCID 0009-0006-8861-0293

Lira NigmatullinaInstitute of Molecular Biology gGmbH, 55128 Mainz, Germany.

Nastasja KreimInstitute of Molecular Biology gGmbH, 55128 Mainz, Germany.

Natalia SoshnikovaInstitute for Molecular Medicine and Research Center for Immunotherapy (FZI), University Medical Center of the Johannes Gutenberg-University, 55131 Mainz, Germany.ORCID 0000-0002-4620-3669

Johannes Gutenberg University Mainz · DEInstitute of Molecular Biology · DE

Funding

Deutsche Forschungsgemeinschaft SO 1738/ 1-1Deutsche Forschungsgemeinschaft SO 1738/ 3-1

6 · The paper itself

Abstract

Continuous and rapid renewal of the intestinal epithelium depends on intestinal stem cells (ISCs). A large repertoire of transcription factors mediates the correct maintenance and differentiation of ISCs along either absorptive or secretory lineages. In the present study, we addressed the role of TCF7L1, a negative regulator of WNT signalling, in embryonic and adult intestinal epithelium using conditional mouse mutants. We found that TCF7L1 prevents precocious differentiation of the embryonic intestinal epithelial progenitors towards enterocytes and ISCs. We show that

Indexed as

Intestinal MucosaStem CellsAnimalsCell DifferentiationIntestinesIntestine, SmallMiceenteroendocrine cellsNotchsmall intestineTCF7L1tuft cellsWNT

Identifiers

PMID37296573

DOI10.3390/cells12111452

PMCPMC10253002

OpenAlexW4378083367

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.