Evidence map›Paper›PMID 37296568›Full record

ArticleCells2023

The Immune Response to SARS-CoV-2 Vaccine in a Cohort of Family Pediatricians from Southern Italy.

Paolo Cortese, Felice Amato, Antonio Davino, Raffaella De Franchis, Speranza Esposito, Immacolata Zollo, Marina Di Domenico, Egle Solito, Federica Zarrilli, Laura Gentile and 2 more

Open access · goldAbstract read
In one paragraph

Article in Cells, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Immune Profile in COVID-19: Unveiling TInternational journal of molecular sciences · 2024
    Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Paolo CorteseFederazione Italiana Medici Pediatri (FIMP), 80142 Naples, Italy.
Felice AmatoDipartimento di Medicina Molecolare e Biotecnologie Mediche, Università di Napoli Federico II, 80131 Naples, Italy.ORCID 0000-0002-0596-2933
Antonio DavinoFederazione Italiana Medici Pediatri (FIMP), 80142 Naples, Italy.
Raffaella De FranchisFederazione Italiana Medici Pediatri (FIMP), 80142 Naples, Italy.
Speranza EspositoCEINGE Biotecnologie Avanzate Franco Salvatore, Scarl, 80131 Naples, Italy.ORCID 0000-0003-0269-4029
Immacolata ZolloDipartimento di Medicina Molecolare e Biotecnologie Mediche, Università di Napoli Federico II, 80131 Naples, Italy.ORCID 0009-0006-1021-9550
Marina Di DomenicoDipartimento di Medicina di Precisione, Università degli Studi della Campania Luigi Vanvitelli, 80138 Naples, Italy.
Egle SolitoCentre for Translational Medicine and Therapeutics William Harvey Research Institute, Queen Mary Univesity, London E1 4NS, UK.
Federica ZarrilliDipartimento di Medicina Molecolare e Biotecnologie Mediche, Università di Napoli Federico II, 80131 Naples, Italy.ORCID 0000-0003-1614-6816
Laura GentileCEINGE Biotecnologie Avanzate Franco Salvatore, Scarl, 80131 Naples, Italy.
Gustavo CerneraDipartimento di Medicina Molecolare e Biotecnologie Mediche, Università di Napoli Federico II, 80131 Naples, Italy.ORCID 0000-0002-1370-9786
Giuseppe CastaldoDipartimento di Medicina Molecolare e Biotecnologie Mediche, Università di Napoli Federico II, 80131 Naples, Italy.
Ceinge Biotecnologie Avanzate (Italy) · ITUniversity of Campania "Luigi Vanvitelli" · ITWilliam Harvey Research Institute · GB

Funding

Italian Ministry of University and Research PRIN 2020, code 20209TB4AXRegione Campania CEINGE TASK-FORCE-2022 COVID19 CUP n. D63C22000570002Regione Campania POR Campania FESR 2014/2020, code SURF 21058BP000000020 CUP B63C22001210007Regione Campania POR Campania FESR2014/2020 O.S. 1.3 AZ. 1.3.1 AVVISO DGR 504 del 10/11/2021 - CUP B63C22001270002University of Naples Federico II 2020 FRA LINEA B
6 · The paper itself

Abstract

In Italy, from January 2021, the Ministry of Health indicated a vaccination plan against COVID for frail patients and physicians based on a three-dose scheme. However, conflicting results have been reported on which biomarkers permit immunization assessment. We used several laboratory approaches (i.e., antibodies serum levels, flow cytometry analysis, and cytokines release by stimulated cells) to investigate the immune response in a cohort of 53 family pediatricians (FPs) at different times after the vaccine. We observed that the BNT162b2-mRNA vaccine induced a significant increase of specific antibodies after the third (booster) dose; however, the antibody titer was not predictive of the risk of developing the infection in the six months following the booster dose. The antigen stimulation of PBMC cells from subjects vaccinated with the third booster jab induced the increase of the activated T cells (i.e., CD4

Indexed as

COVID-19COVID-19 VaccinesBNT162 VaccineHumansImmunityItalyLeukocytes, MononuclearPediatriciansSARS-CoV-2Tumor Necrosis Factor-alphaBNT162 VaccineCOVID-19 VaccinesTumor Necrosis Factor-alphaCOVID-19IFN-γSARS-CoV2 antibodiesT-cellTNF-α

Identifiers

PMID37296568
PMCPMC10252549
OpenAlexW4378085062

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.