ArticleThe Journal of clinical endocrinology and metabolism2023
Obesity, Hyperfiltration, and Early Kidney Damage: A New Formula for the Estimation of Creatinine Clearance.
Article in The Journal of clinical endocrinology and metabolism, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Effects of High-Protein Diets on Renal Function and Body Composition in Adults Without Chronic Kidney Disease: A Systematic Review and Meta-Analysis of Randomised Trials.Diabetes, obesity & metabolism · 2026Pooled it
- Effect of dietary interventions on kidney function in adults with obesity without chronic kidney disease: a systematic review and meta-analysis of randomized controlled trials.Frontiers in nutrition · 2026Pooled it
- Mortality, Renal Replacement Therapy and Renal Impairment Markers in Critically Ill Patients in a Multinational Point-Prevalence ICU Cohort over 2007 to 2024: A nutritionDay Descriptive Multivariable Analysis.Journal of clinical medicine · 2026Article
- Article
- Hyperfiltration in Obesity: The Vicious Link Between Visceral Fat, Proteinuria, and Sodium Excretion.Nutrients · 2026Article
- Article
- Impact of Endoscopic Bariatric and Metabolic Therapies on Chronic Kidney Disease in Patients with Impaired Glycemic Control.Obesity surgery · 2026Observational
- Associations of trimethylamine N-oxide (TMAO) and its precursors with childhood obesity: a case-control study.BMC endocrine disorders · 2025Article
- mTOR blockade prevents progressive proteinuria but induces hyperglycaemia in obese Dahl salt-sensitive rats before puberty.Experimental physiology · 2025Article
- Serum lncRNA-ANRIL and creatinine clearance as cardiovascular risk factors in patients who underwent sleeve gastrectomy.Scientific reports · 2025Article
- Estimation of age and sex-specific Glomerular Filtration Rate and its association with mortality and atherosclerotic cardiovascular outcomes in the Abu Dhabi population; A Retrospective Cohort Study.Journal of nephrology · 2025Article
- Predictors of Dual Phosphodiesterase Type 5 Inhibitor Therapy in Persons With Erectile Dysfunction and Diabetes.Cureus · 2025Article
- Nanoparticle-Delivered Rutin Prevents Metabolic and Oxidative Imbalance in Obesity Triggered by a High-Fat Diet: In Vivo and In Silico Studies.Biomedicines · 2025Article
- Relationship between bmi and glomerular filtration rate in a large cohort initiating a weight loss program: differential contributions of fat mass, fat-free mass, and abdominal fat compartments.Nutrition journal · 2025Article
- Obesity Class and Severity of Metabolic Emergencies: A Single-Center Retrospective Five-Year Study.Healthcare (Basel, Switzerland) · 2025Article
- Obesity as a Risk Factor for Hyperglycemia, Electrolyte Disturbances, and Acute Kidney Injury in the Emergency Department.Biomedicines · 2025Article
- CKD in Bardet-Biedl Syndrome: Evidence Supporting Multifactorial Etiology.Kidney international reports · 2025Article
- Chronic Kidney Disease in Balkan Countries-A Call for Optimal Multidisciplinary Management.International journal of environmental research and public health · 2025Review
- Role of obesity in chronic kidney disease progression.Current research in physiology · 2025Review
- Obesity-Related Kidney Disease in Bariatric Surgery Candidates.Obesity surgery · 2025Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
contextGlomerular hyperfiltration may represent a direct pathogenetic link between obesity and kidney disease. The most widely used methods to estimate creatine clearance such as Cockroft-Gault (CG), Modification of Diet in Renal Disease (MDRD), and Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) have not been validated in subjects with obesity.
objectiveThe performance of prediction formulas was compared with measured creatinine clearance (mCrCl) in subjects with obesity.
methodsThe study population included 342 patients with obesity (mean BMI 47.6 kg/m2) without primary kidney disease. A urine collection was performed over 24 hours for measurement of CrCl.
resultsmCrCl increased with body weight. The CG formula showed an overestimation at high CrCl, whereas an underestimation resulted from CKD-EPI and MDRD. To improve the accuracy of estimated CrCl (eCrCl), a new CG-based formula was developed:53+0.7×(140-Age)×Weight/(96xSCr)×(0.85iffemale)A cut-off point for BMI of 32 kg/m2 was identified, at which the new formula may be applied to improve eCrCl.
conclusionIn patients with obesity the glomerular filtration rate increases with body weight, and it is associated with the presence of albuminuria, suggesting an early kidney injury. We propose a novel formula that improves the accuracy of eCrCl to avoid missed diagnoses of hyperfiltration in patients with obesity.
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