Evidence map›Paper›PMID 37296515›Full record

ReviewThe Journal of clinical endocrinology and metabolism2023

Associations Between Fatigue and Endocrine and Non-endocrine Health Problems in Turner Syndrome: Cohort Study and Review.

Anna G W Rosenberg, Veerle D A Dingemans, Anja G Bos-Roubos, Sanne Luijks, Arianne B Dessens, Ramon Dykgraaf, Jolien W Roos-Hesselink, Elisabeth F C Van Rossum, Aart J Van Der Lely, Laura C G De Graaff

Open access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in The Journal of clinical endocrinology and metabolism, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 2 pooled it
1.9field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 2 syntheses or guidelines pooled it, 6 citations in OpenAlex.

  1. Pooled it
  2. Guideline
  3. Article
  4. Article
  5. Connecting the dots: the role of fatigue in female infertility.Reproductive biology and endocrinology : RB&E · 2024
    Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Anna G W RosenbergInternal Medicine, Division of Endocrinology, Erasmus MC, University Medical Center, 3015 GD Rotterdam, The Netherlands.ORCID 0000-0002-8333-1512
Veerle D A DingemansInternal Medicine, Division of Endocrinology, Erasmus MC, University Medical Center, 3015 GD Rotterdam, The Netherlands.
Anja G Bos-RoubosCenter of Excellence for Neuropsychiatry, Vincent van Gogh Institute for Psychiatry, 5803 AC Venray, The Netherlands.
Sanne LuijksObstetrics and Gynecology, Erasmus MC, University Medical Center, 3015 GD Rotterdam, The Netherlands.
Arianne B DessensTurner Syndrome Reference Center, Erasmus MC, University Medical Center, 3015 GD Rotterdam, The Netherlands.
Ramon DykgraafObstetrics and Gynecology, Erasmus MC, University Medical Center, 3015 GD Rotterdam, The Netherlands.
Jolien W Roos-HesselinkTurner Syndrome Reference Center, Erasmus MC, University Medical Center, 3015 GD Rotterdam, The Netherlands.ORCID 0000-0002-6770-3830
Elisabeth F C Van RossumInternal Medicine, Division of Endocrinology, Erasmus MC, University Medical Center, 3015 GD Rotterdam, The Netherlands.
Aart J Van Der LelyInternal Medicine, Division of Endocrinology, Erasmus MC, University Medical Center, 3015 GD Rotterdam, The Netherlands.ORCID 0000-0002-1059-0126
Laura C G De GraaffInternal Medicine, Division of Endocrinology, Erasmus MC, University Medical Center, 3015 GD Rotterdam, The Netherlands.ORCID 0000-0002-0295-7063
Erasmus MC · NLVincent Van Gogh Voor Geestelijke Gezondheidszorg · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

contextTurner syndrome (TS) is a rare chromosomal disorder characterized by gonadal dysfunction, short stature, and heart defects, among other features. Women with TS often suffer from severe fatigue, for which they are typically referred to endocrinologists. The diagnostic work-up is generally time-consuming and invasive, and it rarely solves the problem. To prevent the personal and financial burden of unnecessary diagnostic procedures, it is crucial to understand fatigue in TS.

objectiveTo explore the association between fatigue and endocrine and non-endocrine comorbidities in a-for rare disorders-large group of women with TS.

methods170 genetically confirmed women with TS who attended the TS Reference Center underwent a systematic health screening, including a structured interview, complete physical examination, biochemical measurements, perceived stress and fatigue questionnaires, and additional tests when indicated.

resultsMedian (interquartile range) age was 32.6 (23.9-41.4) years. Severe fatigue was experienced by 1 in 3 women with TS. Liver enzyme disturbances and body mass index were significantly associated with higher fatigue scores. Perceived stress was highly correlated with fatigue.

conclusionThere was no association between fatigue and most endocrine and non-endocrine disorders, which implies that fatigue is only partly explained by somatic disorders. The high correlation between perceived stress and fatigue suggests that TS-related neuropsychological processes may play an important role in the etiology of fatigue in women with TS. We provide a practical algorithm for the endocrine, non-endocrine, and psychological approach to fatigue in women with TS.

Indexed as

Turner SyndromeAdultBody Mass IndexCohort StudiesComorbidityFemaleHumansadultfatigueinternal medicinepsychologicalstressTurner syndrome

Identifiers

PMID37296515
PMCPMC10655540
OpenAlexW4380153520

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.