ArticleCardiovascular diabetology2023
The change of triglyceride-glucose index may predict incidence of stroke in the general population over 45 years old.
Article in Cardiovascular diabetology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 82 papers, 1 of them a synthesis that pooled it.
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Who cites it
82 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Triglyceride-glucose index and health outcomes: an umbrella review of systematic reviews with meta-analyses of observational studies.Cardiovascular diabetology · 2024Pooled it
- Asymmetric plantar temperature downshifts are associated with atrial fibrillation and thromboembolic events: an observational post hoc analysis of the SmartPreventDiabeticFeet study.Communications medicine · 2026Article
- Sustained estimated VLDL-C exposure is associated with cardiometabolic multimorbidity and foam cell dysfunction: evidence from prospective cohorts andJournal of geriatric cardiology : JGC · 2026Article
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- Association between insulin resistance surrogate markers and cardiovascular disease risk in individuals with subclinical metabolic disorders: a prospective cohort study based on baseline levels, cumulative exposure, and longitudinal trajectories.Cardiovascular diabetology · 2026Article
- Longitudinal changes and cumulative exposure of estimated glucose disposal rate and all-cause mortality in middle-aged and older Chinese adults.Scientific reports · 2026Article
- Integration of triglyceride-glucose index and biological aging to predict cardiovascular disease risk in cardiovascular-kidney-metabolic syndrome stages 0-3: a multiple prospective cohort study.Cardiovascular diabetology · 2026Article
- Joint association of triglyceride-glucose index and atherogenic lipid markers with incident stroke risk.Scientific reports · 2026Article
- Association of combined waist-to-height ratio and systolic blood pressure categories with incident cardiovascular disease in middle-aged and older adults.Scientific reports · 2026Article
- Combined effects of cumulative triglyceride-glucose and blood pressure on stroke in middle-aged and older Chinese adults: a longitudinal analysis.Journal of global health · 2026Article
- Association of the triglyceride glucose-body roundness index with stroke risk in middle-aged and elderly Chinese adults without diabetes: a prospective cohort study.Cardiovascular diagnosis and therapy · 2026Article
- Associations of cumulative exposure and dynamic patterns of the C-reactive protein-triglyceride-glucose index with cardiometabolic multimorbidity in middle-aged and elderly Chinese: a nationwide cohort study.BMC public health · 2026Article
- Associations Between the Modified Cardiometabolic Index and Stroke in Patients With Different Glucose Metabolism Statuses: Evidence From a Nationally Representative Survey.Reviews in cardiovascular medicine · 2026Article
- The predictive value of C-reactive protein-triglycerides-glucose index-waist-to-height ratio for stroke: a nationwide cohort study.Cardiovascular diabetology · 2026Article
- Associations between the CHG index, its modified versions and incident stroke in patients with early-stage CKM syndrome: a nationwide cohort study.European journal of medical research · 2026Article
- Joint Association of Inflammatory-Metabolic Indices With Risk of Incident Stroke Among Middle-Aged and Older Chinese Adults.Journal of obesity · 2026Article
- The association between the C-reactive protein-triglyceride glucose index and myocardial injury after acute ischemic stroke: a machine learning analysis of the brain-heart axis.Frontiers in cardiovascular medicine · 2026Article
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22 more citing papers are in PubMed but not listed here.
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5 authors.
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Abstract
backgroundStroke has been found to be highly correlated with the triglyceride-glucose (TyG) index. The relation between the TyG index changes and stroke, however, has seldom been reported, and current researches mentioning the TyG index concentrate on individual values. We aimed to investigate whether the level and the change of TyG index was associated with the incidence of stroke.
methodsSociodemographic, medical background, anthropometric and laboratory information were retrospectively collected. Classification was conducted using k-means clustering analysis. Logistic regressions were to determine the relationship between different classes with changes in the TyG index and incidence of stroke, taking the class with the smallest change as a reference. Meanwhile, restricted cubic spline regression was applied to examine the links of cumulative TyG index and stroke.
results369 (7.8%) of 4710 participants had a stroke during 3 years. Compared to class 1 with the best control of the TyG Index, the OR for class 2 with good control was 1.427 (95% CI, 1.051-1.938), the OR for class 3 with moderate control was 1.714 (95% CI, 1.245-2.359), the OR for class 4 with worse control was 1.814 (95% CI, 1.257-2.617), and the OR for class 5 with consistently high levels was 2.161 (95% CI, 1.446-3.228). However, after adjusting for multiple factors, only class 3 still had an association with stroke (OR 1.430, 95%CI, 1.022-2.000). The relation between the cumulative TyG index and stroke was linear in restricted cubic spline regression. In subgroup analysis, similar results were shown in participants without diabetes or dyslipidemia. There is neither additive nor multiplicative interaction between TyG index class and covariates.
conclusionA constant higher level with worst control in TyG index indicated a higher risk of stroke.
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