Evidence map›Paper›PMID 37296337›Full record

ArticleInternational journal of hematology2023

Clinical characteristics of late-onset interstitial pneumonia after allogeneic hematopoietic stem cell transplantation.

Nobuharu Fujii, Makoto Onizuka, Takahiro Fukuda, Kazuhiro Ikegame, Toshiro Kawakita, Hirohisa Nakamae, Takeshi Kobayashi, Keisuke Kataoka, Masatsugu Tanaka, Tadakazu Kondo and 8 more

Abstract read
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In one paragraph

Article in International journal of hematology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.6field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 15 institutions in 1 country.

Nobuharu FujiiDepartment of Hematology and Oncology, Okayama University Hospital, 2-5-1 Shikata-Cho, Kita-Ku, Okayama, 700-8558, Japan. nfujii@md.okayama-u.ac.jp.ORCID http://orcid.org/0000-0002-8043-7768
Makoto OnizukaDivision of Hematology/Oncology, Department of Internal Medicine, Tokai University School of Medicine, Isehara, Japan.
Takahiro FukudaDepartment of Hematopoietic Stem Cell Transplantation, National Cancer Center Hospital, Tokyo, Japan.
Kazuhiro IkegameDivision of Hematology, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan.
Toshiro KawakitaDepartment of Hematology, National Hospital Organization Kumamoto Medical Center, Kumamoto, Japan.
Hirohisa NakamaeHematology, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan.
Takeshi KobayashiHematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital, Tokyo, Japan.
Keisuke KataokaDivision of Hematology, Department of Medicine, Keio University School of Medicine, Tokyo, Japan.
Masatsugu TanakaDepartment of Hematology, Kanagawa Cancer Center, Yokohama, Japan.
Tadakazu KondoDepartment of Hematology and Oncology, Kyoto University, Kyoto, Japan.
Koji KatoCentral Japan Cord Blood Bank, Seto, Japan.
Atsushi SatoDepartment of Hematology and Oncology, Miyagi Children's Hospital, Sendai, Japan.
Tatsuo IchinoheDepartment of Hematology and Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan.
Yoshiko AtsutaJapanese Data Center for Hematopoietic Cell Transplantation, Nagakute, Japan.
Masao OgataDepartment of Hematology, Oita University Hospital, Oita, Japan.
Ritsuro SuzukiDepartment of Hematology and Oncology, Shimane University School of Medicine, Izumo, Japan.
Hideki NakasoneDivision of Hematology, Jichi Medical University Saitama Medical Center, Saitama, Japan.
JSTCT Transplant Complications Working Group
Aichi Medical University · JPHiroshima University · JPHyogo Medical University · JPJichi Medical University · JPKanagawa Prefectural Hospital Organization · JPKeio University · JPKumamoto Medical Center · JPKyoto University · JPMiyagi Children's Hospital · JPOita University Hospital · JPOkayama University Hospital · JPOsaka Metropolitan University · JPShimane University · JPTokai University · JPTokyo Metropolitan Komagome Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Non-infectious pulmonary complications after allogeneic hematopoietic stem cell transplantation (HSCT) remain fatal. In particular, information regarding late-onset interstitial lung disease predominantly including organizing pneumonia and interstitial pneumonia (IP) is limited. A retrospective nationwide survey was conducted using data collected from the Japanese transplant outcome registry database from 2005 to 2010. This study focused on patients (n = 73) with IP diagnosed after day 90 post-HSCT. A total of 69 (94.5%) patients were treated with systemic steroids, and 34 (46.6%) experienced improvement. The presence of chronic graft-versus-host disease at the onset of IP was significantly associated with non-improvement of symptoms (odds ratio [OR] 0.35). At the time of last follow-up (median, 1471 days), 26 patients were alive. Of the 47 deaths, 32 (68%) were due to IP. The 3-year overall survival (OS) and non-relapse mortality (NRM) rates were 38.8% and 51.8%, respectively. In the multivariate analysis, the predictive factors for OS were comorbidities at IP onset (hazard ratio [HR]: 2.19) and performance status (PS) score of 2-4 (HR 2.77). Furthermore, cytomegalovirus reactivation requiring early intervention (HR 2.04), PS score of 2-4 (HR 2.63), and comorbidities at IP onset (HR 2.90) were also significantly associated with increased risk of NRM.

Indexed as

Graft vs Host DiseaseHematopoietic Stem Cell TransplantationLung Diseases, InterstitialHumansProportional Hazards ModelsRetrospective StudiesTransplantation, HomologousAllogeneic hematopoietic stem cell transplantationInterstitial lung diseaseInterstitial pneumoniaNon-infectious pulmonary complication

Identifiers

PMID37296337
OpenAlexW4380028895

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.