ArticleCommunications biology2023
Treadmill exercise modulates the medial prefrontal-amygdala neural circuit to improve the resilience against chronic restraint stress.
Article in Communications biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 18 citations in OpenAlex.
- Acute Stress Drives Adaptive Anxiety via Excitatory-Inhibitory Imbalance in the Prefrontal-Amygdala Circuit in Male Mice.Neuroscience bulletin · 2026Article
- Activity of VMS-projecting mPFC neurons encodes individual vulnerability to chronic restraint stress in male mice.Neurobiology of stress · 2026Article
- Treadmill exercise relieves cortical interneuron hyperactivation to prevent stress-induced anxiety-like behaviors in male mice.Communications biology · 2026Article
- Article
- From energy metabolism to mood regulation: The rise of lactate as a therapeutic target.Journal of advanced research · 2026Review
- Exercise as a multiscale recalibration of stress-related homeostatic balance.Frontiers in neuroscience · 2026Review
- Associations of resistance liuzijue qigong with sleep and mood in chronic insomnia: a pilot open-label Non-randomized trial.Frontiers in medicine · 2026Article
- Exercise prescription for mood and cognition: targeting the microbiota-gut-brain axis through short-chain fatty acids.Frontiers in microbiology · 2026Review
- Physical activity, regulatory emotional self-efficacy, and suicidal ideation in adolescents: a variable-centered and person-centered approach.Frontiers in psychology · 2026Article
- The association between weekend warrior physical activity pattern and anxiety: evidence from a U.S. population-based study.BMC psychiatry · 2025Article
- Treadmill exercise prevents stress-induced anxiety-like behaviors via enhancing the excitatory input from the primary motor cortex to the thalamocortical circuit.Nature communications · 2025Article
- The influence of exercise intensity on comorbid anxious behavior in psychiatric conditions.The journal of physiological sciences : JPS · 2024Article
- Transcutaneous auricular vagus nerve stimulation improves social deficits through the inhibition of IL-17a signaling in a mouse model of autism.Frontiers in psychiatry · 2024Article
- Research status and trends of physical activity on depression or anxiety: a bibliometric analysis.Frontiers in neuroscience · 2024Article
- Exercise as an antidepressant: exploring its therapeutic potential.Frontiers in psychiatry · 2023Review
- Unlocking the epigenome: Stress and exercise induced Bdnf regulation in the prefrontal cortex.Neurotoxicology and teratologyArticle
Corrections and comments
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Authors and funding
5 authors at 1 institution in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aerobic exercise effectively ameliorates mental disorders including anxiety and depression. Current findings mainly attribute its neural mechanism to the improvement of adult neurogenesis, while leaving the possible circuitry mechanism unclear. In the current study, we identify the overexcitation of the medial prefrontal cortex (mPFC) to basolateral amygdala (BLA) pathway under chronic restraint stress (CRS), and 14-day treadmill exercise selectively reverses such abnormalities. Using chemogenetic approaches, we find that the mPFC-BLA circuit is necessary for preventing anxiety-like behaviors in CRS mice. These results collectively suggest a neural circuitry mechanism by which exercise training improves the resilience against environmental stress.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.