Evidence map›Paper›PMID 37296240›Full record

ArticleCurrent microbiology2023

Chitosan Microspheres Loaded with Curcumin and Gallic Acid: Modified Synthesis, Sustainable Slow Release, and Enhanced Biological Property.

Yan Lv, Lijia Su, Zihang Zhao, Jinying Zhao, Huahua Su, Zhikai Zhang, Yanhua Wang

Abstract read
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In one paragraph

Article in Current microbiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yan Lv *The Hubei Key Laboratory of Tumor Microenvironment and Immunotherapy, China Three Gorges University, Yichang, 443002, China.
Lijia Su *The Third-Grade Pharmacological Laboratory On Traditional, Chinese Medicine (Approved By State Administration of Traditional Chinese Medicine), China Three Gorges University, Yichang, 443002, China.
Zihang Zhao *The Hubei Key Laboratory of Tumor Microenvironment and Immunotherapy, China Three Gorges University, Yichang, 443002, China.
Jinying ZhaoThe Third-Grade Pharmacological Laboratory On Traditional, Chinese Medicine (Approved By State Administration of Traditional Chinese Medicine), China Three Gorges University, Yichang, 443002, China.
Huahua SuThe Third-Grade Pharmacological Laboratory On Traditional, Chinese Medicine (Approved By State Administration of Traditional Chinese Medicine), China Three Gorges University, Yichang, 443002, China.
Zhikai ZhangThe Hubei Key Laboratory of Tumor Microenvironment and Immunotherapy, China Three Gorges University, Yichang, 443002, China.
Yanhua WangDepartment of Morphology, College of Basic Medical Science, China Three Gorges University, Yichang, 443002, China. juddy0921@163.com.

Funding

China Three Gorges University grant no. 2022KZL2-01National Natural Science Foundation of China grant no. 81602559
6 · The paper itself

Abstract

Improving the utilization rate of loaded-drugs is of huge importance for generating chitosan-based (CS) micro-carriers. This study aims to fabricate a novel CS microspheres co-delivered curcumin (Cur) and gallic acid (Ga) to assess drug loading and release kinetics, the blood compatibility and anti-osteosarcoma properties. The present study observes the interaction between CS and Cur/Ga molecules and estimates the change in crystallinity and loading and release rate. In addition, blood compatibility and cytotoxicity of such microspheres are also evaluated. Cur-Ga-CS microspheres present high entrapment rate of (55.84 ± 0.34) % for Ga and (42.68 ± 0.11) % for Cur, possibly attributed to surface positive charge (21.76 ± 2.46) mV. Strikingly, Cur-Ga-CS microspheres exhibit slowly sustainable release for almost 7 days in physiological buffer. Importantly, these microspheres possess negligibly toxic to blood and normal BMSC cells, but strong anti-osteosarcoma effect on U2OS cells. Overall, Cur-Ga-CS microspheres are promising to become a novel anti-osteosarcoma agent or sustainable delivery carrier in biomedical applications.

Indexed as

ChitosanCurcuminNanoparticlesDrug CarriersMicrospheresChitosanCurcuminDrug Carriers

Identifiers

PMID37296240

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.