ArticleScientific reports2023
Validation of CT-based ventilation and perfusion biomarkers with histopathology confirms radiation-induced pulmonary changes in a porcine model.
Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Functional lung avoidance stereotactic body radiation therapy for central lung cancer patients.Quantitative imaging in medicine and surgery · 2025Article
- Letter to the Editor: Expanding the clinical relevance of dynamic perfusion area-detector CT-recommendations for broader applicability.European radiology · 2025Article
- The draft genome of the Wisconsin Miniature SwineTM, a valuable biomedical research tool.G3 (Bethesda, Md.) · 2025Article
- Hybrid method for estimating lung ventilation from CT by combining intensity and motion information.Medical physics · 2025Article
- A review on functional lung avoidance radiotherapy plan for lung cancer.Frontiers in oncology · 2024Review
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9 authors.
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Abstract
Imaging biomarkers can assess disease progression or prognoses and are valuable tools to help guide interventions. Particularly in lung imaging, biomarkers present an opportunity to extract regional information that is more robust to the patient's condition prior to intervention than current gold standard pulmonary function tests (PFTs). This regional aspect has particular use in functional avoidance radiation therapy (RT) in which treatment planning is optimized to avoid regions of high function with the goal of sparing functional lung and improving patient quality of life post-RT. To execute functional avoidance, detailed dose-response models need to be developed to identify regions which should be protected. Previous studies have begun to do this, but for these models to be clinically translated, they need to be validated. This work validates two metrics that encompass the main components of lung function (ventilation and perfusion) through post-mortem histopathology performed in a novel porcine model. With these methods validated, we can use them to study the nuanced radiation-induced changes in lung function and develop more advanced models.
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