Evidence map›Paper›PMID 37296118›Full record

ArticleNature communications2023

Language network lateralization is reflected throughout the macroscale functional organization of cortex.

Loïc Labache, Tian Ge, B T Thomas Yeo, Avram J Holmes

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
10.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 58 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Language laterality and cognitive skills: does anatomy matter?Cerebral cortex (New York, N.Y. : 1991) · 2026
    Article
  5. Article
  6. Article
  7. Linearizing and Forecasting: A Reservoir Computing Route to Digital Twins of the Brain.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. The molecular and cellular underpinnings of human brain lateralization.bioRxiv : the preprint server for biology · 2025
    Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 4 institutions in 2 countries.

Loïc LabacheDepartment of Psychology, Yale University, New Haven, CT, 06520, US. loic.labache@yale.edu.ORCID 0000-0002-5733-0743
Tian GePsychiatric and Neurodevelopmental Genetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, 02114, US.
B T Thomas YeoDepartment of Electrical and Computer Engineering, Centre for Sleep and Cognition, National University of Singapore, Singapore, SG, 119077, Singapore.ORCID 0000-0002-0119-3276
Avram J HolmesDepartment of Psychology, Yale University, New Haven, CT, 06520, US. avram.holmes@rutgers.edu.ORCID 0000-0001-6583-803X
Broad Institute · USNational University of Singapore · SGRutgers, The State University of New Jersey · USYale University · US

Funding

Mapping the Human Connectome: Structure, Function, and HeritabilityU54MH091657 · NIMH · WASHINGTON UNIVERSITY · PI UGURBIL, KAMIL, VAN ESSEN, DAVID C · 2010 to 2014
$34.7M
Functional genomics of the human connectome in psychiatric illnessR01MH120080 · NIMH · YALE UNIVERSITY · PI AVRAM J HOLMES, Thomas Boon Thye Yeo · 2019 to 2026
$4.8M
Integrative analysis of genomics and imaging data from the BRAIN Initiative and other public data sourcesRF1MH123245 · NIMH · YALE UNIVERSITY · PI GERSTEIN, MARK BENDER, HOLMES, AVRAM J · 2021 to 2021
$1.3M
NIMH NIH HHS R01 MH120080NIMH NIH HHS RF1 MH123245NIMH NIH HHS U54 MH091657
6 · The paper itself

Abstract

Hemispheric specialization is a fundamental feature of human brain organization. However, it is not yet clear to what extent the lateralization of specific cognitive processes may be evident throughout the broad functional architecture of cortex. While the majority of people exhibit left-hemispheric language dominance, a substantial minority of the population shows reverse lateralization. Using twin and family data from the Human Connectome Project, we provide evidence that atypical language dominance is associated with global shifts in cortical organization. Individuals with atypical language organization exhibit corresponding hemispheric differences in the macroscale functional gradients that situate discrete large-scale networks along a continuous spectrum, extending from unimodal through association territories. Analyses reveal that both language lateralization and gradient asymmetries are, in part, driven by genetic factors. These findings pave the way for a deeper understanding of the origins and relationships linking population-level variability in hemispheric specialization and global properties of cortical organization.

Indexed as

Brain MappingFunctional LateralityBrainHumansLanguageMagnetic Resonance Imaging

Identifiers

PMID37296118
PMCPMC10256741
OpenAlexW4380080237

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.