Evidence map›Paper›PMID 37296035›Full record

ArticleTrends in pharmacological sciences2023

Hedgehog signalling in allograft vasculopathy: a new therapeutic target?

Jasmine Rowell, Ching-In Lau, Diana C Yánez, Eden Zhang, Tessa Crompton

Open access · hybridAbstract readComment
PubMed Full text at PMC Publisher
In one paragraph

Article in Trends in pharmacological sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 75% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Jasmine RowellUCL Great Ormond Street Institute of Child Health, London, UK.
Ching-In LauUCL Great Ormond Street Institute of Child Health, London, UK.
Diana C YánezUCL Great Ormond Street Institute of Child Health, London, UK.
Eden ZhangUCL Great Ormond Street Institute of Child Health, London, UK.
Tessa CromptonUCL Great Ormond Street Institute of Child Health, London, UK. Electronic address: t.crompton@ucl.ac.uk.
Great Ormond Street Hospital · GB

Funding

Yale Liver CenterP30DK034989 · NIDDK · YALE UNIVERSITY · PI YASUKO IWAKIRI · 1986 to 2026
$31.1M
THE ROLE OF ZFYVE21 IN CEREBRAL AMYLOID ANGIOPATHY IN ALZHEIMER'S DISEASER01HL141137 · NHLBI · YALE UNIVERSITY · PI JANE-WIT, DANIEL · 2018 to 2022
$2.6M
Intracellular Membrane Attack Complexes and COVID-19 Immune HyperactivationR21AI178582 · NIAID · YALE UNIVERSITY · PI JANE-WIT, DANIEL · 2023 to 2024
$461k
American Heart Association-American Stroke Association 24TPA1280547Biotechnology and Biological Sciences Research Council BB/T020970/1BLRD VA I01 BX005117Medical Research Council MR/S037764/1NHLBI NIH HHS R01 HL141137NIAID NIH HHS R21 AI178582NIDDK NIH HHS P30 DK034989
6 · The paper itself

Abstract

Allograft vasculopathy (AV) leads to chronic rejection of organ transplants, but its causes are obscure. New research from the Jane-Wit laboratory showed that Sonic Hedgehog (SHH) signalling from damaged graft endothelium drives vasculopathy by promoting proinflammatory cytokine production and NLRP3-inflammasome activation in alloreactive CD4

Indexed as

Hedgehog ProteinsSignal TransductionAllograftsHumansHedgehog ProteinsCD4 T cellinflammasomeNLRP3SMOSonic Hedgehog (SHH)ZFYVE21

Identifiers

PMID37296035
PMCPMC11569892
OpenAlexW4379801982

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.