ArticleInternational journal of epidemiology2023
Educational attainment, health outcomes and mortality: a within-sibship Mendelian randomization study.
Article in International journal of epidemiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Socioeconomic position, genetic susceptibility, and epigenetic profiles in obesity across the life course: a systematic review.International journal of obesity (2005) · 2026Pooled it
- Multivariate GWAS framework for family trios with parental phenotypes to control dynastic effects.BMC bioinformatics · 2026Article
- Improving estimation efficiencies for family-based GWAS by integrating large external data.medRxiv : the preprint server for health sciences · 2025Article
- Knowledge attitude and practice of pregnant women on postnatal depression in Henan Province China.Scientific reports · 2025Article
- Migration, educational, and asthma mortality disparities in the United States.The journal of allergy and clinical immunology. In practice · 2025Article
- A robust and powerful GWAS method for family trios supporting within-family Mendelian randomization analysis.Research square · 2025Article
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- Article
- Associations of schooling type, qualification type and subsequent health in mid-adulthood: evidence from the 1970 British Cohort Study.Journal of epidemiology and community health · 2024Article
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- Longitudinal leisure-time physical activity profiles throughout adulthood and related characteristics: a 36-year follow-up study of the older Finnish Twin Cohort.The international journal of behavioral nutrition and physical activity · 2024Article
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- Correlation analysis between occupational stress and metabolic syndrome in workers of a petrochemical enterprise: based on two assessment models of occupational stress.BMC public health · 2024Article
- Distilling causality between physical activity traits and obesity via Mendelian randomization.Communications medicine · 2023Article
- Genetic and Environmental Factors Underlying Parallel Changes in Body Mass Index and Alcohol Consumption: A 36-Year Longitudinal Study of Adult Twins.Obesity facts · 2023Article
Corrections and comments
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Authors and funding
29 authors.
Funding
Abstract
backgroundPrevious Mendelian randomization (MR) studies using population samples (population MR) have provided evidence for beneficial effects of educational attainment on health outcomes in adulthood. However, estimates from these studies may have been susceptible to bias from population stratification, assortative mating and indirect genetic effects due to unadjusted parental genotypes. MR using genetic association estimates derived from within-sibship models (within-sibship MR) can avoid these potential biases because genetic differences between siblings are due to random segregation at meiosis.
methodsApplying both population and within-sibship MR, we estimated the effects of genetic liability to educational attainment on body mass index (BMI), cigarette smoking, systolic blood pressure (SBP) and all-cause mortality. MR analyses used individual-level data on 72 932 siblings from UK Biobank and the Norwegian HUNT study, and summary-level data from a within-sibship Genome-wide Association Study including >140 000 individuals.
resultsBoth population and within-sibship MR estimates provided evidence that educational attainment decreased BMI, cigarette smoking and SBP. Genetic variant-outcome associations attenuated in the within-sibship model, but genetic variant-educational attainment associations also attenuated to a similar extent. Thus, within-sibship and population MR estimates were largely consistent. The within-sibship MR estimate of education on mortality was imprecise but consistent with a putative effect.
conclusionsThese results provide evidence of beneficial individual-level effects of education (or liability to education) on adulthood health, independently of potential demographic and family-level confounders.
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