Evidence map›Paper›PMID 37295810›Full record

ArticleStroke and vascular neurology2024

Pipeline Embolization Device for intracranial aneurysms presenting with mass effect: a large Chinese cohort.

Yang Zhao, Junlin Lu, Hongqi Zhang, Tianxiao Li, Donglei Song, Sheng Guan, Aisha Maimaitili, Yunyan Wang, Wenfeng Feng, Yang Wang and 6 more

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stroke and vascular neurology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03831672 (Post Market Multi-Center Retrospective Research on Embolization of Intracranial Aneurysms With Pipeline Embolization Device in China), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03831672 unknown statusnot on this map

Post Market Multi-Center Retrospective Research on Embolization of Intracranial Aneurysms With Pipeline Embolization Device in China (PLUS)

TypeobservationalSponsorBeijing Neurosurgical InstituteRan2018 to 2019Enrolled200ConditionsIntracranial Aneurysm, Pipeline Embolization Device
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors at 7 institutions in 1 country.

Yang Zhao *Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.ORCID 0000-0001-8774-6945
Junlin Lu *Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu, Sichuan, China.ORCID 0000-0003-4879-0729
Hongqi ZhangDepartment of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China.
Tianxiao LiDepartment of Interventional Neuroradiology, Zhengzhou University People's Hospital, Zhengzhou, Henan, China.
Donglei SongDepartment of Neurosurgery, Shanghai Donglei Brain Hospital, Shanghai, China.
Sheng GuanDepartment of Interventional Neuroradiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Aisha MaimaitiliDepartment of Neurosurgery, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, China.
Yunyan WangDepartment of Neurosurgery, Qilu Hospital of Shandong University Qingdao, Jinan, Shandong, China.
Wenfeng FengDepartment of Neurosurgery, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Yang WangDepartment of Neurosurgery, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.
Jieqing WanDepartment of Neurosurgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Guohua MaoDepartment of Neurosurgery, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.
Huaizhang ShiDepartment of Neurosurgery, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China.
Xinjian YangDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Jianmin LiuDepartment of Neurosurgery, Changhai Hospital, Naval Medical University, Shanghai, China.
Yuanli ZhaoDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China zhaoyuanli@bjtth.org.
Capital Medical University · CNNanchang University · CNSecond Military Medical University · CNXinjiang Medical University · CNFirst Affiliated Hospital of Zhengzhou University · CNHarbin Medical University · CNZhengzhou University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundUnruptured intracranial aneurysm treatment aims to reduce the risk of aneurysm rupture and bleeding, relieves symptoms and improve the quality of life for patients. This study aimed to assess the safety and efficacy of Pipeline Embolization Device (PED, Covidien/Medtronic, Irvine, CA) treatment for intracranial aneurysms presenting with mass effect in real-world settings.

methodsWe selected patients from the PED in China Post-Market Multi-Center Registry Study with mass effect presentation. The study endpoints included postoperative mass effect deterioration and mass effect relief at follow-up (3-36 months). We conducted multivariate analysis to identify factors associated with mass effect relief. Subgroup analyses by aneurysm location, size and form were also performed.

resultsThis study included 218 patients with a mean age of 54.3±11.8 years and a female predominance of 74.0% (162/218). The postoperative mass effect deterioration rate was 9.6% (21/218). During a median follow-up period of 8.4 months, the mass effect relief rate was 71.6% (156/218). Notably, immediate aneurysm occlusion following treatment was significantly associated with mass effect relief (OR 0.392, 95% CI, 0.170 to 0.907, p=0.029). Subgroup analysis demonstrated that adjunctive coiling contributed to mass effect relief in cavernous aneurysms, while dense embolism impeded symptom relief in aneurysms<10 mm and saccular aneurysms.

conclusionsOur data confirmed the efficacy of PED in relieving mass effect. The findings of this study provide support for endovascular treatment to alleviate mass effect in unruptured intracranial aneurysms. TRIAL REGISTRATION NUMBER: NCT03831672.

Indexed as

Embolization, TherapeuticIntracranial AneurysmAdultAgedFemaleFollow-Up StudiesHumansMaleMiddle AgedQuality of LifeTreatment Outcomeaneurysmflow diverterrisk factorsstents

Identifiers

PMID37295810
PMCPMC10956105
OpenAlexW4380085752

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.