Evidence map›Paper›PMID 37295719›Full record

ArticleAmerican journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons2023

Intragraft B cell differentiation during the development of tolerance to kidney allografts is associated with a regulatory B cell signature revealed by single cell transcriptomics.

Michael Tyler Guinn, Edward S Szuter, Takahiro Yokose, Jifu Ge, Ivy A Rosales, Kashish Chetal, Ruslan I Sadreyev, Alex G Cuenca, Daniel Kreisel, Peter T Sage and 4 more

Open access · hybridAbstract read
In one paragraph

Article in American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 19 citations in OpenAlex.

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  7. Can mouse kidney transplant models inform mechanisms of injury and acceptance in clinical kidney transplantation?American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2025
    Review
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  10. Science translational medicine · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 1 country.

Michael Tyler GuinnMichael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas, USA; Center for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital, Boston, Massachusetts, USA.
Edward S SzuterCenter for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital, Boston, Massachusetts, USA.
Takahiro YokoseCenter for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital, Boston, Massachusetts, USA.
Jifu GeBoston's Children Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Ivy A RosalesCenter for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital, Boston, Massachusetts, USA; Department of Pathology, Massachusetts General Hospital, Boston, Massachusetts, USA.
Kashish ChetalDepartment of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts, USA.
Ruslan I SadreyevDepartment of Pathology, Massachusetts General Hospital, Boston, Massachusetts, USA; Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts, USA.
Alex G CuencaBoston's Children Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Daniel KreiselDepartments of Surgery, Pathology, and Immunology, Washington University School of Medicine, St. Louis, Missouri, USA.
Peter T SageTransplantation Research Center, Renal Division, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Paul S RussellCenter for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital, Boston, Massachusetts, USA.
Joren C MadsenCenter for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital, Boston, Massachusetts, USA; Division of Cardiac Surgery, Massachusetts General Hospital, Boston, Massachusetts, USA.
Robert B ColvinCenter for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital, Boston, Massachusetts, USA; Department of Pathology, Massachusetts General Hospital, Boston, Massachusetts, USA.
Alessandro AlessandriniCenter for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital, Boston, Massachusetts, USA. Electronic address: alessand@helix.mgh.harvard.edu.
Massachusetts General Hospital · USBoston Children's Hospital · USBrigham and Women's Hospital · USMichael E. DeBakey VA Medical Center · USWashington University in St. Louis · US

Funding

Project 3: Enhanced Costimulation Blockade to Achieve Clinically Relevant Heart Allograft ToleranceP01HL158504 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI MADSEN, JOREN C · 2021 to 2025
$12.1M
Project 3: The Role of Erythropoietin in Kidney Transplant ToleranceP01AI123086 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI MADSEN, JOREN C · 2016 to 2020
$10.6M
Mixed chimerism induced tolerance in heart recipients requires donor kidney cotransplantationU01AI131470 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI MADSEN, JOREN C · 2017 to 2022
$5.6M
NHLBI NIH HHS P01 HL158504NIAID NIH HHS P01 AI123086NIAID NIH HHS U01 AI131470
6 · The paper itself

Abstract

Mouse kidney allografts are spontaneously accepted in select, fully mismatched donor-recipient strain combinations, like DBA/2J to C57BL/6 (B6), by natural tolerance. We previously showed accepted renal grafts form aggregates containing various immune cells within 2 weeks posttransplant, referred to as regulatory T cell-rich organized lymphoid structures, which are a novel regulatory tertiary lymphoid organ. To characterize the cells within T cell-rich organized lymphoid structures, we performed single-cell RNA sequencing on CD45

Indexed as

B-Lymphocytes, RegulatoryAllograftsAnimalsCell DifferentiationGraft RejectionGraft SurvivalKidneyMiceMice, Inbred C57BLMice, Inbred DBATranscriptomeB cell biologyimmunogeneticsinformaticskidney transplantationmolecular biologytolerance

Identifiers

PMID37295719
PMCPMC11232115
OpenAlexW4380046963

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.