Evidence map›Paper›PMID 37295542›Full record

ReviewClinical immunology (Orlando, Fla.)2023

Immunopathogenesis of Behçet's disease.

Arshed F Al-Obeidi, Johannes Nowatzky

Abstract readReview
In one paragraph

Review in Clinical immunology (Orlando, Fla.), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Behçet's Disease: A Comprehensive Review on the Role ofInternational journal of molecular sciences · 2023
    Pooled it
  2. Observational
  3. SerumInternational journal of molecular sciences · 2026
    Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Interpreting the Function of the IL-23/IL-17 Axis through Bioinformatics.Endocrine, metabolic & immune disorders drug targets · 2025
    Review
  14. [Update on Behçet syndrome].Zeitschrift fur Rheumatologie · 2024
    Review
  15. Article
  16. Review
  17. Deficiency of peripheral CLAArthritis research & therapy · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Arshed F Al-ObeidiNew York University Grossman School of Medicine, Department of Medicine, New York, NY, USA.
Johannes NowatzkyNew York University Grossman School of Medicine, Department of Medicine, New York, NY, USA; New York University Grossman School of Medicine, Department of Pathology, USA; New York University Grossman School of Medicine, Department of Medicine, Division of Rheumatology, NYU Langone Ocular Rheumatology Program, New York, NY, USA; New York University Grossman School of Medicine, Department of Medicine, Division of Rheumatology, NYU Langone Center for Behçet's Disease, New York, NY, USA. Electronic address: Johannes.Nowatzky@nyumc.org.

Funding

Unraveling the role of HLA-B51/ERAP1 in Behcet's eye diseaseR01EY031383 · NEI · STANFORD UNIVERSITY · PI NOWATZKY, JOHANNES · 2021 to 2025
$2.1M
Modulation of immunodominance in HLA class I associated uveitidesR01EY033495 · NEI · STANFORD UNIVERSITY · PI NOWATZKY, JOHANNES · 2022 to 2025
$1.8M
NEI NIH HHS R01 EY031383NEI NIH HHS R01 EY033495
6 · The paper itself

Abstract

Behçet's disease (BD) is a multi-system inflammatory disorder with vasculitic features. It does not suit any of the current pathogenesis-driven disease classifications well, a unifying concept of its pathogenesis is not unanimously conceivable at present, and its etiology is obscure. Still, evidence from immunogenetic and other studies supports the notion of a complex-polygenic disease with robust innate effector responses, reconstitution of regulatory T cells upon successful treatment, and first clues to the role of an, as of yet, underexplored adaptive immune system and its antigen recognition receptors. Without an attempt to be comprehensive, this review aims to collect and organize impactful parts of this evidence in a way that allows the reader to appreciate the work done and define the efforts needed now. The focus is on literature and notions that drove the field into new directions, whether recent or more remote.

Indexed as

Behcet SyndromeHLA-B51 AntigenHLA-B AntigensHumansT-Lymphocytes, RegulatoryHLA-B51 AntigenHLA-B AntigensAntigen-recognitionBehcetCD8 T cellsERAP1HLA-B51NK cells

Identifiers

PMID37295542
PMCPMC10484394

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.