ArticleNeuron2023
Mouse frontal cortex mediates additive multisensory decisions.
Article in Neuron, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed.
- A circuit dissection of perception-action decoupling in S-ketamine-induced hallucination-like states.Molecular psychiatry · 2026Article
- Cholinergic-dependent dopamine signals in mouse dorsomedial striatum are regulated by frontal but not sensory cortices.Nature communications · 2026Article
- In-depth characterization of the CaScientific reports · 2026Article
- Multisensory integration of stimulus-driven and goal-driven signals during urgent saccadic choices.bioRxiv : the preprint server for biology · 2026Article
- Cortex-wide characterization of decision-making neural dynamics during spatial navigation.Nature communications · 2026Article
- Visuomotor decision-making through multifeature convergence in the larval zebrafish hindbrain.Nature communications · 2026Article
- Integration of learned artificial sensation with vision during freely moving navigation.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Bees flexibly adjust decision strategies to information content in a foraging task.Science advances · 2026Article
- Pan-cortical cellular imaging in freely behaving mice using a miniaturized micro-camera array microscope (mini-MCAM).Science advances · 2025Article
- Behavioural and neuronal insights into multisensory combination of unpracticed cues.bioRxiv : the preprint server for biology · 2025Article
- Working memory expands shared task representations in cortex.bioRxiv : the preprint server for biology · 2025Article
- Parallel and convergent pathways for multifeature visual processing in larval zebrafish sensorimotor decision-making.bioRxiv : the preprint server for biology · 2025Article
- Decoding decision-making behavior from sparse neural spiking activity.PLoS computational biology · 2025Article
- Fusing multisensory signals across channels and time.PLoS computational biology · 2025Article
- Article
- Locomotion-dependent auditory gating to the parietal cortex guides multisensory decisions.Nature communications · 2025Article
- Article
- Gustatory cortex neurons perform reliability-dependent integration of multisensory flavor inputs.Current biology : CB · 2025Article
- Article
- An adaptable, reusable, and light implant for chronic Neuropixels probes.bioRxiv : the preprint server for biology · 2024Article
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5 authors.
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Abstract
The brain can combine auditory and visual information to localize objects. However, the cortical substrates underlying audiovisual integration remain uncertain. Here, we show that mouse frontal cortex combines auditory and visual evidence; that this combination is additive, mirroring behavior; and that it evolves with learning. We trained mice in an audiovisual localization task. Inactivating frontal cortex impaired responses to either sensory modality, while inactivating visual or parietal cortex affected only visual stimuli. Recordings from >14,000 neurons indicated that after task learning, activity in the anterior part of frontal area MOs (secondary motor cortex) additively encodes visual and auditory signals, consistent with the mice's behavioral strategy. An accumulator model applied to these sensory representations reproduced the observed choices and reaction times. These results suggest that frontal cortex adapts through learning to combine evidence across sensory cortices, providing a signal that is transformed into a binary decision by a downstream accumulator.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.