Evidence map›Paper›PMID 37295171›Full record

ArticleJournal of stroke and cerebrovascular diseases : the official journal of National Stroke Association2023

Outcomes of heart transplant recipients with prior left ventricular assist device associated stroke.

Aaron Shoskes, Merry Huang, Catherine Hassett, Randall C Starling, Eileen Hsich, Edward Soltesz, Sung-Min Cho, Ken Uchino

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 93% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Aaron ShoskesDepartment of Neurology, Neurological Institute, Cleveland Clinic, 9500 Euclid Avenue s100a, Cleveland, OH 44195, USA. Electronic address: Aaron.Shoskes@gmail.com.
Merry HuangDepartment of Neurology, Neurological Institute, Cleveland Clinic, 9500 Euclid Avenue s100a, Cleveland, OH 44195, USA.
Catherine HassettCerebrovascular Center, Neurological Institute, Cleveland Clinic, Cleveland, OH, , USA.
Randall C StarlingDepartment of Cardiovascular Medicine, Heart, Vascular, and Thoracic Institute, Cleveland Clinic, Cleveland, OH, USA.
Eileen HsichDepartment of Cardiovascular Medicine, Heart, Vascular, and Thoracic Institute, Cleveland Clinic, Cleveland, OH, USA.
Edward SolteszDepartment of Thoracic and Cardiovascular Surgery, Heart, Vascular, and Thoracic Institute, Cleveland Clinic, Cleveland, OH, USA.
Sung-Min ChoDivision of Neuroscience Critical Care, Departments of Neurology, Neurosurgery, Anesthesiology, and Critical Care Medicine, Johns Hopkins University, Baltimore, MD, USA.
Ken UchinoCerebrovascular Center, Neurological Institute, Cleveland Clinic, Cleveland, OH, , USA.
Cleveland Clinic · USJohns Hopkins University · US

Funding

Impact of Disparities Affecting Survival among Advanced Heart Failure Patients and Transplant RecipientsR01HL141892 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI HSICH, EILEEN MICHELLE, ISHWARAN, HEMANT · 2018 to 2021
$2.8M
Real time risk prognostication via scalable hazard trees and forestsR01HL164405 · NHLBI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI Hemant Ishwaran · 2023 to 2026
$2.3M
CLots and Oxygen in Va-ExtracorpoReal membrane oxygenation (CLOVER) studyK23HL157610 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI Sung-Min Cho · 2022 to 2026
$797k
NHLBI NIH HHS K23 HL157610NHLBI NIH HHS R01 HL141892NHLBI NIH HHS R01 HL164405
6 · The paper itself

Abstract

backgroundLeft ventricular assist devices (LVADs) improve survival in patients with end-stage heart failure but are associated with ischemic stroke and intracranial hemorrhage (ICH). The impact of LVAD-associated stroke on transplant candidacy and outcomes has not been characterized.

methodsAdult patients undergoing LVAD implantation at Cleveland Clinic between 2004 to 2021 were reviewed and patients who developed ischemic stroke or ICH were identified. Post-transplant survival analysis was performed between patients with LVAD-associated stroke vs. without.

results917 patients had an LVAD implantation of whom 244 (median age 57, 79% male) underwent subsequent transplant including 25 with prior LVAD-associated stroke. The 1- and 2-year survival after transplant in patients with LVAD-associated stroke were 100% and 95% respectively, compared with 92% and 90% in patients without stroke (p=0.156; p=0.323) Similarly, there was no difference in stroke incidence at 1- and 2 years after transplant between patients with LVAD-associated stroke (4% and 5%) and those without prior stroke (5% and 6%, p = 0.884; p=0.744).

conclusionsIn this single-center retrospective study, patients with LVAD-associated stroke were significantly less likely to undergo heart transplant, but those who underwent heart transplant had similar post-transplant outcomes as patients without history of LVAD-associated stroke. Given the similar outcomes seen in this population, history of LVAD-associated stroke should not be viewed as an absolute contraindication to subsequent heart transplant.

Indexed as

Heart-Assist DevicesHeart FailureHeart TransplantationIschemic StrokeStrokeAdultFemaleHumansIntracranial HemorrhagesMaleMiddle AgedRetrospective StudiesTreatment OutcomeIntracranial hemorrhageIschemic strokeLeft ventricular assist deviceStrokeTransplant

Identifiers

PMID37295171
PMCPMC10881273
OpenAlexW4379662140

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.