Evidence map›Paper›PMID 37294874›Full record

ArticleJournal of the American Chemical Society2023

Tuning the Type 1 Reduction Potential of Multicopper Oxidases: Uncoupling the Effects of Electrostatics and H-Bonding to Histidine Ligands.

Asmita Singha, Alina Sekretareva, Lizhi Tao, Hyeongtaek Lim, Yang Ha, Augustin Braun, Stephen M Jones, Britt Hedman, Keith O Hodgson, R David Britt and 2 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the American Chemical Society, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
8.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 21 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Asmita SinghaDepartment of Chemistry, Stanford University, Stanford, California 94305, United States.ORCID 0000-0001-5512-253X
Alina SekretarevaDepartment of Chemistry, Stanford University, Stanford, California 94305, United States.ORCID 0000-0001-7312-0116
Lizhi TaoDepartment of Chemistry, University of California at Davis, Davis, California 95616, United States.
Hyeongtaek LimDepartment of Chemistry, Stanford University, Stanford, California 94305, United States.ORCID 0000-0003-3470-8296
Yang HaDepartment of Chemistry, Stanford University, Stanford, California 94305, United States.
Augustin BraunDepartment of Chemistry, Stanford University, Stanford, California 94305, United States.ORCID 0000-0002-9487-5769
Stephen M JonesDepartment of Chemistry, Stanford University, Stanford, California 94305, United States.ORCID 0000-0003-2045-1661
Britt HedmanStanford Synchrotron Radiation Lightsource, SLAC National Accelerator Laboratory, Stanford University, Menlo Park, California 94025, United States.
Keith O HodgsonDepartment of Chemistry, Stanford University, Stanford, California 94305, United States.
R David BrittDepartment of Chemistry, University of California at Davis, Davis, California 95616, United States.ORCID 0000-0003-0889-8436
Daniel J KosmanDepartment of Biochemistry, The University at Buffalo, Buffalo, New York 14214, United States.ORCID 0000-0003-3570-7682
Edward I SolomonDepartment of Chemistry, Stanford University, Stanford, California 94305, United States.ORCID 0000-0003-0291-3199
Stanford University · USSLAC National Accelerator Laboratory · USUniversity of California, Davis · USUniversity at Buffalo, State University of New York · US

Funding

A Synchrotron Radiation Structural Biology ResourcesP30GM133894 · NIGMS · STANFORD UNIVERSITY · PI Ritimukta Sarangi · 2020 to 2026
$43.3M
Structure/Function Correlations Over Copper EnzymesR01DK031450 · NIDDK · STANFORD UNIVERSITY · PI EDWARD I SOLOMON · 1986 to 2026
$8.7M
Supplement:Spectroscopy Investigations of Metalloenzyme MechanismsR35GM126961 · NIGMS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI R. David Britt · 2018 to 2026
$3.7M
Spectroscopic Characterization of Oxygen Intermediates in Non-heme and Heme Iron EnzymesR35GM145202 · NIGMS · STANFORD UNIVERSITY · PI EDWARD I SOLOMON · 2022 to 2026
$2.0M
NIDDK NIH HHS R01 DK031450NIGMS NIH HHS P30 GM133894NIGMS NIH HHS R35 GM126961NIGMS NIH HHS R35 GM145202
6 · The paper itself

Abstract

In multicopper oxidases (MCOs), the type 1 (T1) Cu accepts electrons from the substrate and transfers these to the trinuclear Cu cluster (TNC) where O

Indexed as

CeruloplasminHistidineCopperLaccaseLigandsStatic ElectricityTrametesCeruloplasminCopperHistidineLaccaseLigands

Identifiers

PMID37294874
PMCPMC10392966
OpenAlexW4379981429

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.