ArticleScience advances2023
Translational imaging of TSPO reveals pronounced innate inflammation in human and murine CD8 T cell-mediated limbic encephalitis.
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Article in Science advances, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14citing papers in PubMed
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14 citing papers in PubMed, 26 citations in OpenAlex.
- Effectiveness and safety of efgartigimod in patients with anti-NMDAR or anti-LGI1 encephalitis and itsNeuroprotection (Chichester, England) · 2026Article
- Forkhead box versus NF-κB hippocampal snRNA-seq profiles distinguish anti-Drebrin- and anti-GAD65-positive encephalitis.Journal of neuroinflammation · 2026Article
- Neuroimmune activation in temporal lobe epilepsy patients with worsening seizure following the COVID-19 pandemic: A [Science advances · 2026Article
- Recurrent spatial disorientation and amnestic episodes associated with lung adenocarcinoma: a serum- and CSF-negative paraneoplastic case.Archive of clinical cases · 2026Article
- Activated αβ T and reduced mucosa-associated invariant T cells in LGI1- and CASPR2-encephalitis.Brain : a journal of neurology · 2025Article
- A scoping review on potential of novel developments in fever of unknown origin and inflammation of unknown origin: long-axial-field-of-view positron emission tomography/computed tomography and novel radiotracers.The quarterly journal of nuclear medicine and molecular imaging : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of... · 2025Article
- Autoimmune encephalitis-associated epilepsy.Nature reviews. Neurology · 2025Review
- Evaluation of the Utility of Hybrid PET/MR Neuroimaging in Inflammatory Demyelination and Encephalitis.Journal of clinical medicine · 2025Review
- Microglial Activation Visualized by [European journal of neurology · 2025Article
- Hybrid PET/MRI Imaging of 18F-Fluorodeoxyglucose and 18-kDa Translocator Protein for Presurgical Localization in Refractory Epilepsy.CNS neuroscience & therapeutics · 2025Article
- Increased TSPO alleviates neuropathic pain by preventing pyroptosis via the AMPK-PGC-1α pathway.The journal of headache and pain · 2025Article
- Radiopharmaceuticals and their applications in medicine.Signal transduction and targeted therapy · 2025Review
- [Journal of neurology · 2024Article
- Increased cysteinyl-tRNA synthetase drives neuroinflammation in Alzheimer's disease.Translational neurodegeneration · 2024Article
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Authors and funding
36 authors at 8 institutions in 5 countries.
Marco GallusDepartment of Neurology Institute of Translational Neurology, University of Münster, Münster, Germany.ORCID 0009-0007-4954-8420
Wolfgang RollDepartment of Nuclear Medicine, University of Münster, Münster, Germany.ORCID 0000-0002-3746-9393
Andre DikDepartment of Neurology Institute of Translational Neurology, University of Münster, Münster, Germany.ORCID 0000-0003-4695-4136
Cristina BarcaEuropean Institute for Molecular Imaging, University of Münster, Münster, Germany.ORCID 0000-0001-8034-2948
Bastian ZinnhardtEuropean Institute for Molecular Imaging, University of Münster, Münster, Germany.
Gordon HickingDepartment of Neurology Institute of Translational Neurology, University of Münster, Münster, Germany.
Christoph MuellerDepartment of Neurology Institute of Translational Neurology, University of Münster, Münster, Germany.ORCID 0000-0003-1844-8009
Venu Narayanan NaikDepartment of Neurology Institute of Translational Neurology, University of Münster, Münster, Germany.ORCID 0000-0002-3637-4173
Max AnstötzInstitute of Anatomy II, Medical Faculty, University Hospital Düsseldorf, Heinrich-Heine-University, Düsseldorf, Germany.
Julia KrämerDepartment of Neurology Institute of Translational Neurology, University of Münster, Münster, Germany.
Leoni RolfesDepartment of Neurology Institute of Translational Neurology, University of Münster, Münster, Germany.
Lydia WachsmuthDepartment of Clinical Radiology, University of Münster, Münster, Germany.
Julika PitschDepartment of Epileptology, University of Bonn, Bonn, Germany.ORCID 0000-0002-6688-4916
Karen M J van LooSection for Translational Epilepsy Research, Department of Neuropathology, University of Bonn, Bonn, Germany.
Saskia RäuberDepartment of Neurology Institute of Translational Neurology, University of Münster, Münster, Germany.ORCID 0000-0001-8901-5572
Hideho OkadaDepartment of Neurosurgery, University of California, San Francisco, San Francisco, CA, USA.ORCID 0000-0003-0076-9920
Catriona WimberleyEdinburgh Imaging, University of Edinburgh, Edinburgh, UK.ORCID 0000-0002-2709-6837
Christine StrippelDepartment of Neurology Institute of Translational Neurology, University of Münster, Münster, Germany.
Kristin S GolombeckDepartment of Neurology Institute of Translational Neurology, University of Münster, Münster, Germany.
Andreas JohnenDepartment of Neurology Institute of Translational Neurology, University of Münster, Münster, Germany.
Stjepana KovacDepartment of Neurology Institute of Translational Neurology, University of Münster, Münster, Germany.ORCID 0000-0002-2500-6893
Catharina C GroßDepartment of Neurology Institute of Translational Neurology, University of Münster, Münster, Germany.ORCID 0000-0002-4872-9189
Philipp BackhausDepartment of Nuclear Medicine, University of Münster, Münster, Germany.ORCID 0000-0003-4164-4104
Robert SeifertDepartment of Nuclear Medicine, University of Münster, Münster, Germany.ORCID 0000-0001-5985-7701
Jan LewerenzDepartment of Neurology, University of Ulm, Ulm, Germany.ORCID 0000-0002-9272-529X
Rainer SurgesDepartment of Epileptology, University of Bonn, Bonn, Germany.ORCID 0000-0002-3177-8582
Christian E ElgerDepartment of Epileptology, University of Bonn, Bonn, Germany.ORCID 0009-0008-3245-6017
Heinz WiendlDepartment of Neurology Institute of Translational Neurology, University of Münster, Münster, Germany.ORCID 0000-0003-4310-3432
Tobias RuckDepartment of Neurology Institute of Translational Neurology, University of Münster, Münster, Germany.ORCID 0000-0001-6332-8650
Albert J BeckerSection for Translational Epilepsy Research, Department of Neuropathology, University of Bonn, Bonn, Germany.
Cornelius FaberDepartment of Clinical Radiology, University of Münster, Münster, Germany.
Andreas H JacobsEuropean Institute for Molecular Imaging, University of Münster, Münster, Germany.
Jan BauerDepartment of Neuroimmunology, Centre for Brain Research, Medical University of Vienna, Vienna, Austria.ORCID 0000-0001-5802-8047
Sven G MeuthDepartment of Neurology Institute of Translational Neurology, University of Münster, Münster, Germany.ORCID 0000-0003-2571-3501
Michael SchäfersDepartment of Nuclear Medicine, University of Münster, Münster, Germany.ORCID 0000-0002-4008-2755
Nico MelzerDepartment of Neurology Institute of Translational Neurology, University of Münster, Münster, Germany.ORCID 0000-0002-2420-701X
University of Münster · DEUniversity of Bonn · DEUniversity of California, San Francisco · USDüsseldorf University Hospital · DEMedical University of Vienna · ATRoche (Switzerland) · CHUniversität Ulm · DEUniversity of Edinburgh · GB
Funding
Preclinical development of breakthrough immunotherapy for brain tumorsR35NS105068 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI OKADA, HIDEHO · 2018 to 2025
$6.0MAustrian Science Fund FWF P 34864NINDS NIH HHS R35 NS105068
Abstract
Autoimmune limbic encephalitis (ALE) presents with new-onset mesial temporal lobe seizures, progressive memory disturbance, and other behavioral and cognitive changes. CD8 T cells are considered to play a key role in those cases where autoantibodies (ABs) target intracellular antigens or no ABs were found. Assessment of such patients presents a clinical challenge, and novel noninvasive imaging biomarkers are urgently needed. Here, we demonstrate that visualization of the translocator protein (TSPO) with [
Indexed as
Limbic EncephalitisAnimalsAutoimmune DiseasesCarrier ProteinsHumansInflammationMicePositron-Emission TomographyReceptors, GABABzrp protein, mouseCarrier ProteinsReceptors, GABATSPO protein, human
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