ArticleScience immunology2023
Rapid recruitment and IFN-I-mediated activation of monocytes dictate focal radiotherapy efficacy.
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Article in Science immunology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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29citing papers in PubMed
5.1field-weighted citation impact, top 4% of its field
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Who cites it
29 citing papers in PubMed, 31 citations in OpenAlex.
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- Analysis of long non-coding RNAs associated with disulfidptosis for prognostic signature and immunotherapy response in uterine corpus endometrial carcinoma.Scientific reports · 2023Trial
- Challenges and opportunities in combining radiotherapy and immunotherapy for localized pancreatic cancer.Nature reviews. Gastroenterology & hepatology · 2026Review
- Radiotherapy and immunotherapy in cancer treatment: mechanisms of clinical synergy.The Journal of clinical investigation · 2026Review
- Combinatorial Delivery of Low-Dose Radiotherapy and Immunotherapy to Patients with Immune-Excluded Tumors Enhances CD8+ T-cell Functionality.Clinical cancer research : an official journal of the American Association for Cancer Research · 2026Article
- Neoadjuvant BO-112 and Hypofractionated Radiation Therapy with or without Nivolumab in Soft-Tissue Sarcoma: Preclinical and Phase I Results.Cancer discovery · 2026Article
- DNA-damaging chemotherapy reshapes cardiac-resident macrophage composition and function.Science immunology · 2026Article
- Higher pre-treatment lymphocyte-to-monocyte ratio predicts better tumor shrinkage after external beam radiotherapy in locally advanced cervical cancer.Frontiers in oncology · 2026Article
- Rational modulation of immune mechanisms synergizes the anti-tumor effects of targeted radiation therapy in pre-clinical models.Frontiers in immunology · 2026Article
- Beyond density: mapping the functional landscapes of macrophage-T lymphocyte niches in the tumor microenvironment.Frontiers in immunology · 2026Review
- Immune Modulation in the Tumor Microenvironment: Bifurcation Analysis of Cancer-CTL-Monocyte Dynamics.Bulletin of mathematical biology · 2025Article
- Distinct immune cell dynamics associated with immune-related adverse events during combined chemoradiation and immune checkpoint inhibitor therapy.Nature communications · 2025Article
- Distinct Roles of Monocyte Subsets in Cancer.Cells · 2025Review
- Targeting the unfolded protein response for cancer therapy: mitigating tumor adaptation and immune suppression.Biomarker research · 2025Review
- STING agonists drive recruitment and intrinsic type I interferon responses in monocytic lineage cells for optimal anti-tumor immunity.Journal of immunology (Baltimore, Md. : 1950) · 2025Article
- Radiation-Induced Immune Responses from the Tumor Microenvironment to Systemic Immunity.Cancers · 2025Review
- Evaluation of Proton Minibeam Radiotherapy on Antitumor Immune Responses in a Rat Model of Glioblastoma.Cancer immunology research · 2025Article
- Positive and negative roles of myeloid cells in cancer immunotherapy.Journal for immunotherapy of cancer · 2025Review
- The microbiota in radiotherapy-induced cancer immunosurveillance.Nature reviews. Clinical oncology · 2025Review
- Epigenomic preconditioning of peripheral monocytes determines their transcriptional response to the tumor microenvironment.Genome medicine · 2025Article
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Authors and funding
19 authors at 8 institutions in 6 countries.
Sirimuvva TadepalliDepartment of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305-5101, USA.ORCID 0000-0001-9658-9988
Derek R ClementsDepartment of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305-5101, USA.ORCID 0000-0002-0796-8845
Sanjana SaravananDepartment of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305-5101, USA.ORCID 0000-0002-5974-7710
Rebeca Arroyo HorneroDepartment of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305-5101, USA.ORCID 0000-0001-7026-7358
Anja LüdtkeDepartment of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305-5101, USA.
Beau BlackmoreDepartment of Biology, University of Prince Edward Island, Charlottetown, PE C1A 4P3, Canada.ORCID 0009-0002-2552-6335
Joao A PauloDepartment of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0002-4291-413X
Andres Gottfried-BlackmoreDepartment of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305-5101, USA.ORCID 0000-0002-3563-3727
David SeongDepartment of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305-5101, USA.ORCID 0000-0002-8980-5731
Soyoon ParkDepartment of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305-5101, USA.ORCID 0000-0002-7399-411X
Leslie ChanImmunology Program, Stanford University School of Medicine, Stanford, CA 94304, USA.ORCID 0000-0002-5064-140X
Benjamin J KopeckyCenter for Cardiovascular Research, Departmental of Medicine, Cardiovascular Division, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID 0000-0002-9087-6254
Zhaoyuan LiuShanghai Institute of Immunology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.ORCID 0000-0002-3117-0833
Florent GinhouxShanghai Institute of Immunology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.ORCID 0000-0002-2857-7755
Kory J LavineCenter for Cardiovascular Research, Departmental of Medicine, Cardiovascular Division, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID 0000-0003-1948-9945
John Patrick MurphyDepartment of Biology, University of Prince Edward Island, Charlottetown, PE C1A 4P3, Canada.
Matthias MackDepartment of Nephrology, University Hospital Regensburg, Regensburg 93053, Germany.ORCID 0000-0002-3157-7262
Edward E GravesDepartment of Radiation Oncology, Molecular Imaging Program at Stanford, Stanford University School of Medicine, Stanford, CA 94305-5101, USA.ORCID 0000-0003-4265-9041
Juliana IdoyagaDepartment of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305-5101, USA.ORCID 0000-0002-4430-8862
Stanford University · USUniversity of Prince Edward Island · CAWashington University in St. Louis · USAgency for Science, Technology and Research · SGHarvard University · USShanghai Jiao Tong University · CNStanford Medicine · USUniversity Hospital Regensburg · DE
Funding
Translational Oncology Research Program (Project-005)P30CA124435 · NCI · STANFORD UNIVERSITY · PI Vittorio Sebastiano · 2007 to 2026
$71.4MTUMOR HYPOXIA--MOLECULAR STUDIES &CLINICAL EXPLOITATIONP01CA067166 · NCI · STANFORD UNIVERSITY · PI GIACCIA, AMATO J. · 1996 to 2017
$25.5MInstitutional Career Development Core (KL2)KL2TR003143 · NCATS · STANFORD UNIVERSITY · PI ASCH, STEVEN M. · 2019 to 2023
$8.7MSpecification and Function of Tissue Resident and Recruited Macrophages in Cardiac Remodeling and Heart FailureR35HL161185 · NHLBI · WASHINGTON UNIVERSITY · PI Kory J. Lavine · 2022 to 2026
$4.3MAdvancing Multiplexed Isobaric Tag-based Strategies for Proteome ProfilingR01GM132129 · NIGMS · HARVARD MEDICAL SCHOOL · PI PAULO, JOAO A · 2019 to 2023
$1.7MEffect of radiotherapy on dendritic cell subsets: implications for immunotherapyR01CA219994 · NCI · STANFORD UNIVERSITY · PI IDOYAGA, JULIANA · 2017 to 2021
$1.6MDissecting the Role of Donor CCR2- Macrophages During Acute Cellular Rejection After Heart TransplantationK08HL159359 · NHLBI · WASHINGTON UNIVERSITY · PI Benjamin J Kopecky · 2022 to 2026
$757kCyTOFS10OD016318 · OD · STANFORD UNIVERSITY · PI NOLAN, GARRY P · 2013 to 2013
$600kSmall Animal Radiation Research Platform @ StanfordS10OD018208 · OD · STANFORD UNIVERSITY · PI GRAVES, EDWARD E. · 2014 to 2014
$600kNCATS NIH HHS KL2 TR003143NCI NIH HHS P01 CA067166NCI NIH HHS P30 CA124435NCI NIH HHS R01 CA219994NHLBI NIH HHS K08 HL159359NHLBI NIH HHS R35 HL161185NIGMS NIH HHS R01 GM132129NIH HHS S10 OD016318NIH HHS S10 OD018208
Abstract
The recruitment of monocytes and their differentiation into immunosuppressive cells is associated with the low efficacy of preclinical nonconformal radiotherapy (RT) for tumors. However, nonconformal RT (non-CRT) does not mimic clinical practice, and little is known about the role of monocytes after RT modes used in patients, such as conformal RT (CRT). Here, we investigated the acute immune response induced by after CRT. Contrary to non-CRT approaches, we found that CRT induces a rapid and robust recruitment of monocytes to the tumor that minimally differentiate into tumor-associated macrophages or dendritic cells but instead up-regulate major histocompatibility complex II and costimulatory molecules. We found that these large numbers of infiltrating monocytes are responsible for activating effector polyfunctional CD8
Indexed as
Interferon Type INeoplasmsCell DifferentiationHumansLymphocytes, Tumor-InfiltratingMonocytesTumor MicroenvironmentInterferon Type I
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.