Evidence map›Paper›PMID 37294744›Full record

ArticleBiochemistry2023

Rapid Kinetics of Pistol Ribozyme: Insights into Limits to RNA Catalysis.

Suhyun Yoon, Edward Ollie, Darrin M York, Joseph A Piccirilli, Michael E Harris

Abstract read
In one paragraph

Article in Biochemistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Suhyun YoonDepartment of Chemistry, University of Florida, Gainesville, Florida 32611, United States.ORCID 0000-0002-3764-0381
Edward OllieDepartment of Chemistry, University of Florida, Gainesville, Florida 32611, United States.
Darrin M YorkDepartment of Chemistry and Chemical Biology, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854, United States.ORCID 0000-0002-9193-7055
Joseph A PiccirilliDepartment of Chemistry and Department of Biochemistry and Molecular Biology, The University of Chicago, Chicago, Illinois 60637, United States.ORCID 0000-0002-0541-6270
Michael E HarrisDepartment of Chemistry, University of Florida, Gainesville, Florida 32611, United States.ORCID 0000-0001-8977-4392

Funding

Multi-Scale Quantum Models for Ribozyme CatalysisR01GM062248 · NIGMS · UNIVERSITY OF MINNESOTA TWIN CITIES · PI Darrin M York · 2001 to 2026
$7.1M
Structure and Function of Non-Coding RNAR35GM149336 · NIGMS · UNIVERSITY OF CHICAGO · PI Joseph Anthony Piccirilli · 2023 to 2026
$2.8M
Specificity in Substrate Recognition and Catalysis by RNA Processing EnzymesR35GM127100 · NIGMS · UNIVERSITY OF FLORIDA · PI HARRIS, MICHAEL E. · 2018 to 2022
$1.6M
The VS Ribozyme: Catalytic Mechanism, Transition State Structure, and EvolutionR01GM131568 · NIGMS · UNIVERSITY OF CHICAGO · PI PICCIRILLI, JOSEPH ANTHONY · 2019 to 2022
$1.4M
NIGMS NIH HHS R01 GM062248NIGMS NIH HHS R01 GM131568NIGMS NIH HHS R35 GM127100NIGMS NIH HHS R35 GM149336
6 · The paper itself

Abstract

Pistol ribozyme (Psr) is a distinct class of small endonucleolytic ribozymes, which are important experimental systems for defining fundamental principles of RNA catalysis and designing valuable tools in biotechnology. High-resolution structures of Psr, extensive structure-function studies, and computation support a mechanism involving one or more catalytic guanosine nucleobases acting as a general base and divalent metal ion-bound water acting as an acid to catalyze RNA 2'-

Indexed as

RNA, CatalyticCatalysisKineticsMagnesiumNucleic Acid ConformationRNAMagnesiumRNARNA, Catalytic

Identifiers

PMID37294744
PMCPMC10330772

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.