ArticleTAG. Theoretical and applied genetics. Theoretische und angewandte Genetik2023
Identification of quantitative trait loci and candidate genes for seed folate content in soybean.
Article in TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 6 citations in OpenAlex.
- Leveraging weighted embedding and Transformer architecture to improve phenotype prediction of complex traits for crops.Nature communications · 2026Article
- High-resolution quantitative trait loci mapping and pyramiding effects of candidate genes for plant height in soybean.The plant genome · 2026Article
- A Comprehensive Review of Fortification, Bioavailability, and Health Benefits of Folate.International journal of molecular sciences · 2025Review
- High resolution QTL mapping and candidate gene mining for seed oil content and fatty acid composition in soybean.BMC plant biology · 2025Article
- Biological, dietetic and pharmacological properties of vitamin BNPJ science of food · 2025Review
- Integrating QTL mapping with transcriptome analysis mined candidate genes of growth stages in castor (Ricinus communis L.).BMC genomics · 2025Article
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Authors and funding
14 authors at 1 institution in 1 country.
Funding
Abstract
key messageFrom 61 QTL mapped, a stable QTL cluster of 992 kb was discovered on chromosome 5 for folate content and a putative candidate gene, Glyma.05G237500, was identified. Folate (vitamin B9) is one of the most essential micronutrients whose deficiencies lead to various health defects in humans. Herein, we mapped the quantitative trait loci (QTL) underlying seed folate content in soybean using recombinant inbred lines developed from cultivars, ZH35 and ZH13, across four environments. We identified 61 QTL on 12 chromosomes through composite interval mapping, with phenotypic variance values ranging from 1.68 to 24.68%. A major-effect QTL cluster (qFo-05) was found on chromosome 5, spanning 992 kb and containing 134 genes. Through gene annotation and single-locus haplotyping analysis of qFo-05 in a natural soybean population, we identified seven candidate genes significantly associated with 5MTHF and total folate content in multiple environments. RNA-seq analysis showed a unique expression pattern of a hemerythrin RING zinc finger gene, Glyma.05G237500, between both parental cultivars during seed development, which suggest the gene might regulate folate content in soybean. This is the first study to investigate QTL underlying folate content in soybean and provides new insight for molecular breeding to improve folate content in soybean.
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