Evidence map›Paper›PMID 37294407›Full record

ArticleJournal of endocrinological investigation2024

Development and validation of survival nomograms for patients with differentiated thyroid cancer with distant metastases: a SEER Program-based study.

Q Ma, Z Chen, Y Fang, X Wei, N Wang, X Zhou, S Li, C Ying

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Article in Journal of endocrinological investigation, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

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0cells of the map it votes in
7citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
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  5. [Analysis of risk factors for lymph node metastasis in patients with CN0 papillary thyroid carcinoma].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2024
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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Q Ma *Department of Endocrinology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, China.
Z Chen *Department of Endocrinology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, China.
Y FangDepartment of Endocrinology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, China.
X WeiDepartment of Endocrinology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, China.
N WangDepartment of Endocrinology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, China.
X ZhouLaboratory of Morphology, Xuzhou Medical University, Xuzhou, Jiangsu, China.
S LiClinical Research Institute, Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, China.
C YingDepartment of Endocrinology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, China. ycj321651@163.com.ORCID http://orcid.org/0000-0002-0224-0265

Funding

National Natural Science Foundation of China 81701298National Natural Science Foundation of China 82271205Postdoctoral Research Foundation of China 2019M651970
6 · The paper itself

Abstract

backgroundWe aimed to develop a nomogram model of overall survival (OS) and cancer-specific survival (CSS) in patients with differentiated thyroid cancer with distant metastases, and to evaluate and validate the nomogram. Also, its prognostic value was compared with that of the 8th edition of the American Joint Committee on Cancer tumor-node-metastasis staging system (AJCC8SS).

methodsPatients with distant metastatic differentiated thyroid cancer (DMDTC) from 2004 to 2015 were selected from the Surveillance, Epidemiology, and End Results (SEER) Program to extract the clinical variables used for analysis. A total of 906 patients were divided into a training set (n = 634) and validation set (n = 272). OS and CSS were selected as the primary end point and secondary end point. LASSO regression analysis and multivariate Cox regression analysis were applied to screen variables for constructing OS and CSS nomograms for survival probability at 3, 5, and 10 years. Nomograms were evaluated and validated using the consistency index (C-index), time-dependent receiver operator characteristic (ROC) curves, area under the ROC curve, calibration curves, and decision curve analysis (DCA). The predictive survival of the nomogram was compared with that of AJCC8SS. Kaplan-Meier curves and log-rank tests were used to evaluate the risk-stratification ability OS and CSS nomograms.

resultsCS and CSS nomograms included six independent predictors: age, marital status, type of surgical procedure, lymphadenectomy, radiotherapy, and T stage. The C-index for the OS nomogram was 0.7474 (95% CI = 0.7199-0.775), and that for the CSS nomogram was 0.7572 (0.7281-0.7862). The nomogram showed good agreement with the "ideal" calibration curve in the training set and validation sets. DCA confirmed that the survival probability predicted by the nomogram had high clinical predictive value. The nomogram could stratify patients more accurately, and showed more robust accuracy and predictive power, than AJCC8SS.

conclusionsWe established and validated prognostic nomograms for patients with DMDTC, which had significant clinical value compared with AJCC8SS.

Indexed as

AdenocarcinomaThyroid NeoplasmsHumansNeoplasm StagingNomogramsPrognosisSEER ProgramDifferentiated thyroid cancerDistant metastasesNomogramSEER ProgramSurvival

Identifiers

PMID37294407

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