Evidence map›Paper›PMID 37294264›Full record

ArticleJACC. Clinical electrophysiology2023

Conduction Velocity Dispersion Predicts Postinfarct Ventricular Tachycardia Circuit Sites and Associates With Lipomatous Metaplasia.

Lingyu Xu, Sohail Zahid, Mirmilad Khoshknab, Juwann Moss, Ronald D Berger, Jonathan Chrispin, David Callans, Francis E Marchlinski, Stefan L Zimmerman, Yuchi Han and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JACC. Clinical electrophysiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Translational approach to ventricular innervation: the posterior descending ganglionated plexus.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2025
    Article
  4. Reply to: Stochastic virtual heart model predictions.Nature cardiovascular research · 2025
    Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Lingyu XuCardiovascular Medicine Division, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA. Electronic address: Lingyu.Xu@pennmedicine.upenn.edu.
Sohail ZahidDepartment of Internal Medicine, NYU Langone Medical Center, New York, New York, USA.
Mirmilad KhoshknabCardiovascular Medicine Division, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA.
Juwann MossCardiovascular Medicine Division, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA.
Ronald D BergerDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland, USA; Department of Cardiology, Johns Hopkins University, Baltimore, Maryland, USA.
Jonathan ChrispinDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland, USA; Department of Cardiology, Johns Hopkins University, Baltimore, Maryland, USA.
David CallansCardiovascular Medicine Division, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA.
Francis E MarchlinskiCardiovascular Medicine Division, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA.
Stefan L ZimmermanDepartment of Radiology and Radiological Sciences, Johns Hopkins University, Baltimore, Maryland, USA.
Yuchi HanCardiovascular Medicine Division, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA.
Benoit DesjardinsDepartment of Radiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA.
Natalia TrayanovaDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland, USA.
Saman NazarianCardiovascular Medicine Division, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA. Electronic address: https://twitter.com/Dr_Nazarian_EP.

Funding

Infarct-related Ventricular Tachycardia Mechanisms: From Micro to ClinicalR01HL142496 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI TRAYANOVA, NATALIA A. · 2019 to 2022
$3.1M
Implications of Intra-Myocardial Fat Deposition upon Propensity for Malignant ArrhythmiaR01HL142893 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI NAZARIAN, SAMAN, TRAYANOVA, NATALIA A. · 2018 to 2021
$2.5M
NHLBI NIH HHS R01 HL142496NHLBI NIH HHS R01 HL142893
6 · The paper itself

Abstract

backgroundRegional myocardial conduction velocity (CV) dispersion has not been studied in postinfarct patients with ventricular tachycardia (VT).

objectivesThis study sought to compare the following: 1) the association of CV dispersion vs repolarization dispersion with VT circuit sites; and 2) myocardial lipomatous metaplasia (LM) vs fibrosis as the anatomic substrate for CV dispersion.

methodsAmong 33 postinfarct patients with VT, we characterized dense and border zone infarct tissue by late gadolinium enhancement cardiac magnetic resonance, and LM by computed tomography, with both images registered with electroanatomic maps. Activation recovery interval (ARI) was the time interval from the minimum derivative within the QRS complex to the maximum derivative within the T-wave on unipolar electrograms. CV at each EAM point was the mean CV between that point and 5 adjacent points along the activation wave front. CV and ARI dispersion were the coefficient of variation (CoV) of CV and ARI per American Heart Association (AHA) segment, respectively.

resultsRegional CV dispersion exhibited a much larger range than ARI dispersion, with median 0.65 vs 0.24; P < 0.001. CV dispersion was a more robust predictor of the number of critical VT sites per AHA segment than ARI dispersion. Regional LM area was more strongly associated with CV dispersion than fibrosis area. LM area was larger (median 0.44 vs 0.20 cm

conclusionsRegional CV dispersion more strongly predicts VT circuit sites than repolarization dispersion, and LM is a critical substrate for CV dispersion.

Indexed as

Myocardial InfarctionTachycardia, VentricularArrhythmias, CardiacContrast MediaFibrosisGadoliniumHumansContrast MediaGadoliniumchronic myocardial infarctionconduction velocity dispersionlipomatous metaplasiarefractory period dispersionventricular tachycardia

Identifiers

PMID37294264
PMCPMC11149171

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.