Evidence map›Paper›PMID 37294255›Full record

ArticleThe Journal of adolescent health : official publication of the Society for Adolescent Medicine2023

A Developmental Science Approach to Informing Age Subgroups in Adolescent and Young Adult Cancer Research.

Elizabeth J Siembida, Kaitlyn M Fladeboe, Edward Ip, Brad Zebrack, Mallory A Snyder, John M Salsman

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of adolescent health : official publication of the Society for Adolescent Medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
7.0field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 1 country.

Elizabeth J SiembidaInstitute of Health System Science, Northwell Health, Manhasset, New York; Northwell Health Cancer Institute, Northwell Health, Manhasset, New York. Electronic address: esiembida@northwell.edu.
Kaitlyn M FladeboeDepartment of Pediatrics, University of Washington School of Medicine, Seattle, Washington; Ben Towne Center for Childhood Cancer Research, Seattle Children's Research Institute, Seattle, Washington.
Edward IpDepartment of Biostatistics and Data Science, Wake Forest School of Medicine, Winston-Salem, North Carolina; Wake Forest Baptist Comprehensive Cancer Center, Winston-Salem, North Carolina.
Brad ZebrackUniversity of Michigan School of Social Work, Ann Arbor, Michigan; University of Michigan Rogel Cancer Center, Ann Arbor, Michigan.
Mallory A SnyderOffice of Research, The University of Chicago, Chicago, Illinois.
John M SalsmanWake Forest Baptist Comprehensive Cancer Center, Winston-Salem, North Carolina; Department of Social Sciences & Health Policy, Wake Forest School of Medicine, Winston-Salem, North Carolina.
Atrium Health Wake Forest Baptist · USNorthwell Health · USSeattle Children's Hospital · USUniversity of Chicago · USUniversity of Michigan · US

Funding

Tumor Tissue CoreP30CA012197 · NCI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Ruben A. Mesa · 1985 to 2026
$55.4M
Social genomic mechanisms of health disparities among Adolescent and Young Adult (AYA) cancer survivorsR01CA261752 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ZEBRACK, BRADLEY JAY · 2021 to 2025
$3.7M
Optimizing health related quality of life measurement in adolescent and young adult oncology: A PROMISing solutionR01CA218398 · NCI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI SALSMAN, JOHN · 2017 to 2021
$2.6M
Using MOST to EMPOWER: Optimizing an Emotion Regulation Intervention to Enhance Well-being Among Young Adult Cancer SurvivorsR01CA242849 · NCI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI MOSKOWITZ, JUDITH T., SALSMAN, JOHN · 2019 to 2022
$1.4M
Addressing Social Needs of Adolescents and Young Adults (AYAs) with CancerK99CA267481 · NCI · SEATTLE CHILDREN'S HOSPITAL · PI FLADEBOE, KAITLYN MARIE · 2022 to 2023
$230k
NCI NIH HHS K99 CA267481NCI NIH HHS P30 CA012197NCI NIH HHS R01 CA218398NCI NIH HHS R01 CA242849NCI NIH HHS R01 CA261752
6 · The paper itself

Abstract

purposeAdolescent and young adult (AYA; diagnosed ages 15-39) cancer survivors are developmentally heterogenous, and this population consists of at least three distinct theoretically informed subgroups, as follows: adolescents, emerging adults, and young adults. However, there are limited evidence-based recommendations for delineating the validity of these subgroups in cancer-specific research. We sought to inform recommended chronological age ranges for each subgroup based on developmental processes.

methodsThe data were collected using a 2x3 stratified sampling design (on-vs. off-treatment; ages 15-17, 18-25, 26-39) and a cross-sectional survey. AYAs (N = 572) completed three subscales of the Inventory of Dimensions of Emerging Adulthood (identity exploration, experimentation/possibilities, and other-focused), and we used regression tree analyses to identify distinct shifts in mean subscale scores that would indicate unique subgroups. Models included (a) chronological age, (b) chronological age + cancer-related variables, and (c) chronological age + sociodemographic/psychosocial variables as predictors of each developmental measure.

resultsThe recommended age ranges for AYA survivors receiving active treatment were consistent with prior research as follows: adolescents ages 15-17, emerging adults ages 18-24, and young adults ages 25-39. Models for off-treatment survivors suggested four distinct subgroups: adolescents ages 15-17, emerging adults ages 18-23, and 'younger' (ages 24-32) and 'older' young adults (ages 33-39). No sociodemographic or psychosocial variables meaningfully shifted these recommendations. DISCUSSION: Our results suggest that three developmental subgroups remain appropriate for on-treatment survivors, but a second young adult subgroup (ages 33-39) emerged for off-treatment survivors. Therefore, development disruptions may be more likely to occur or manifest in post-treatment survivorship.

Indexed as

Cancer SurvivorsNeoplasmsAdolescentAdultCross-Sectional StudiesEmpirical ResearchHumansResearch DesignYoung Adultadolescent and young adultcancerdevelopmentdevelopmental science

Identifiers

PMID37294255
PMCPMC10524106
OpenAlexW4379911543

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.