Evidence map›Paper›PMID 37293702›Full record

ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2023

T-SPOT.TB Reactivity in Southern African Children With and Without in Utero Human Immunodeficiency Virus Exposure.

Saori C Iwase, Paul T Edlefsen, Lynnette Bhebhe, Kesego Motsumi, Sikhulile Moyo, Anna-Ursula Happel, Danica Shao, Nicholas Mmasa, Sara Schenkel, Melanie A Gasper and 11 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
0.2field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 1 citations in OpenAlex.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 12 institutions in 7 countries.

Saori C IwaseDivision of Immunology, Department of Pathology, University of Cape Town, Cape Town, South Africa.
Paul T EdlefsenVaccine and Infectious Disease Division, Statistical Center for HIV/AIDS Research and Prevention, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
Lynnette BhebheBotswana Harvard AIDS Institute Partnership, Gaborone, Botswana.
Kesego MotsumiBotswana Harvard AIDS Institute Partnership, Gaborone, Botswana.
Sikhulile MoyoBotswana Harvard AIDS Institute Partnership, Gaborone, Botswana.
Anna-Ursula HappelDivision of Immunology, Department of Pathology, University of Cape Town, Cape Town, South Africa.
Danica ShaoVaccine and Infectious Disease Division, Statistical Center for HIV/AIDS Research and Prevention, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
Nicholas MmasaSurgical Department, County Durham and Darlington NHS Trust, Darlington Memorial Hospital, Darlington, United Kingdom.
Sara SchenkelDivision of Pediatric Global Health, Massachusetts General Hospital, Boston, Massachusetts, USA.
Melanie A GasperCenter for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, Washington, USA.
Melanie DuboisDivision of Pediatric Global Health, Massachusetts General Hospital, Boston, Massachusetts, USA.
Megan A FilesDepartment of Medicine, University of Washington School of Medicine, Seattle, Washington, USA.
Chetan SeshadriDepartment of Medicine, University of Washington School of Medicine, Seattle, Washington, USA.
Fergal DuffyCenter for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, Washington, USA.
John AitchisonCenter for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, Washington, USA.ORCID 0000-0002-9153-6497
Mihai G NeteaDepartment of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, The Netherlands.
Jennifer JaoBotswana Harvard AIDS Institute Partnership, Gaborone, Botswana.
Donald W CameronDivisions of Infectious Diseases and Respirology, University of Ottawa at the Ottawa Hospital, Ottawa, Canada.
Clive M GrayDivision of Immunology, Department of Pathology, University of Cape Town, Cape Town, South Africa.
Heather B JaspanDivision of Immunology, Department of Pathology, University of Cape Town, Cape Town, South Africa.
Kathleen M PowisBotswana Harvard AIDS Institute Partnership, Gaborone, Botswana.
Infectious Disease Research Institute · USUniversity of Cape Town · ZABotswana Harvard AIDS Institute Partnership · BWFred Hutch Cancer Center · USHarvard University · USUniversity of Washington · USBoston Children's Hospital · USDarlington Memorial Hospital · GBMassachusetts General Hospital · USNorthwestern University · USUniversity of Bonn · DEUniversity of Ottawa · CA

Funding

PROGRAM FOR AIDS CLINICAL RESEARCH TRAINING (PACRT)T32AI007433 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI MARK J SIEDNER · 1992 to 2026
$11.4M
Immune correlates of tuberculosis and non-tuberculosis infectious morbidity in Southern African HIV-exposed, uninfected infants.R01AI142670 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI POWIS, KATHLEEN · 2019 to 2023
$4.0M
The Tshilo Dikotla Study: Metabolic Outcomes of Children HIV/ARV-Exposed Uninfected in BotswanaR01DK109881 · NIDDK · LURIE CHILDREN'S HOSPITAL OF CHICAGO · PI JAO, JENNIFER · 2016 to 2020
$3.0M
Mucosal microbiome and vaccine responses in HIV-exposed African infantsR01AI120714 · NIAID · SEATTLE CHILDREN'S HOSPITAL · PI JASPAN, HEATHER BERYL · 2016 to 2020
$2.2M
Mechanisms of altered immune responses in HIV exposed infantsR21HD083344 · NICHD · UNIVERSITY OF CAPE TOWN · PI GRAY, CLIVE MAURICE, JASPAN, HEATHER BERYL · 2015 to 2016
$415k
Mechanisms by which trophoblasts recruit T cells to the placental villi during maternal HIV and CMV co-infectionR21HD103498 · NICHD · MAYO CLINIC ROCHESTER · PI CHAKRABORTY, RANA, GRAY, CLIVE MAURICE · 2020 to 2021
$390k
NIAID NIH HHS R01 AI142670NIAID NIH HHS T32 AI007433NICHD NIH HHS R21 HD083344NICHD NIH HHS R21 HD103498NIDDK NIH HHS R01 DK109881
6 · The paper itself

Abstract

Infants who are human immunodeficiency virus (HIV)-exposed uninfected (iHEU) experience higher risk of infectious morbidity than infants HIV-unexposed uninfected (iHUU). We compared tuberculosis (TB) infection prevalence in 418 Bacillus Calmette-Guérin vaccinated sub-Saharan African iHEU and iHUU aged 9-18 months using T-SPOT.TB. Prevalence of TB infection was low and did not differ by HIV exposure status.

Indexed as

HIV InfectionsLatent TuberculosisTuberculosisChildHIVHumansInfantPrevalenceHIV exposureinfantsSouthern AfricaTB infectionT-SPOT.TB

Identifiers

PMID37293702
PMCPMC10573724
OpenAlexW4379966734

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.