ArticleFrontiers in aging neuroscience2023
Education differentiates cognitive performance and resting state fMRI connectivity in healthy aging.
Article in Frontiers in aging neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Functional and effective EEG connectivity patterns in Alzheimer's disease and mild cognitive impairment: a systematic review.Frontiers in aging neuroscience · 2025Pooled it
- Resting state brain activity and association with transfer of cognitive training gains.Neuroimage. Reports · 2026Article
- Brain resting state functional connectivity changes with aerobic exercise, and mindfulness: A narrative review.Sports medicine and health science · 2026Review
- Exploring the association and mediation between educational attainment and intracerebral hemorrhage: an integrated Mendelian randomization and global burden of disease analysis.Neurosurgical review · 2025Article
- Physical activity and network attack tolerance preserve motor function in Parkinson's disease: A pilot study.NPJ Parkinson's disease · 2025Article
- Protective role of parenthood on age-related brain function in mid- to late-life.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Right hemisphere engagement in language abilities in older adults: indication of compensation rather than decline.Frontiers in aging · 2025Article
- Educational disparities in brain health and dementia across Latin America and the United States.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Dynamic properties in functional connectivity changes and striatal dopamine deficiency in Parkinson's disease.Human brain mapping · 2024Article
- Aperiodic component of EEG power spectrum and cognitive performance are modulated by education in aging.Scientific reports · 2024Article
- Childhood engagement in cognitively stimulating activities moderates relationships between brain structure and cognitive function in adulthood.Neurobiology of aging · 2024Article
- Article
- Diagnostic accuracy of heart rate variability as a screening tool for mild neurocognitive disorder.Frontiers in aging neuroscience · 2024Article
- ISLAND Campus: a fee-free formal university educational intervention in mid- to later-life to reduce modifiable risk factors for dementia and improve cognition.Frontiers in aging neuroscience · 2024Article
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Authors and funding
6 authors.
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Abstract
Objectives: In healthy aging, the way people cope differently with cognitive and neural decline is influenced by exposure to cognitively enriching life-experiences. Education is one of them, so that in general, the higher the education, the better the expected cognitive performance in aging. At the neural level, it is not clear yet how education can differentiate resting state functional connectivity profiles and their cognitive underpinnings. Thus, with this study, we aimed to investigate whether the variable education allowed for a finer description of age-related differences in cognition and resting state FC. Methods: We analyzed in 197 healthy individuals (137 young adults aged 20-35 and 60 older adults aged 55-80 from the publicly available LEMON database), a pool of cognitive and neural variables, derived from magnetic resonance imaging, in relation to education. Firstly, we assessed age-related differences, by comparing young and older adults. Then, we investigated the possible role of education in outlining such differences, by splitting the group of older adults based on their education. Results: In terms of cognitive performance, older adults with higher education and young adults were comparable in language and executive functions. Interestingly, they had a wider vocabulary compared to young adults and older adults with lower education. Concerning functional connectivity, the results showed significant age- and education-related differences within three networks: the Visual-Medial, the Dorsal Attentional, and the Default Mode network (DMN). For the DMN, we also found a relationship with memory performance, which strengthen the evidence that this network has a specific role in linking cognitive maintenance and FC at rest in healthy aging. Discussion: Our study revealed that education contributes to differentiating cognitive and neural profiles in healthy older adults. Also, the DMN could be a key network in this context, as it may reflect some compensatory mechanisms relative to memory capacities in older adults with higher education.
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