Evidence map›Paper›PMID 37293656›Full record

ArticleChemical science2023

High-throughput determination of enantiopurity in atroposelective synthesis of aryl triazoles.

Jongdoo Lim, Melody Guo, Sooyun Choi, Scott J Miller, Eric V Anslyn

Abstract read
In one paragraph

Article in Chemical science, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jongdoo LimDepartment of Chemistry, The University of Texas at Austin Austin Texas 78712 USA anslyn@austin.utexas.edu.ORCID https://orcid.org/0000-0001-8309-4484
Melody GuoDepartment of Chemistry, Yale University New Haven Connecticut 06520-8107 USA scott.miller@yale.edu.ORCID https://orcid.org/0000-0001-6085-8306
Sooyun ChoiDepartment of Chemistry, Yale University New Haven Connecticut 06520-8107 USA scott.miller@yale.edu.
Scott J MillerDepartment of Chemistry, Yale University New Haven Connecticut 06520-8107 USA scott.miller@yale.edu.ORCID https://orcid.org/0000-0001-7817-1318
Eric V AnslynDepartment of Chemistry, The University of Texas at Austin Austin Texas 78712 USA anslyn@austin.utexas.edu.ORCID https://orcid.org/0000-0002-5137-8797

Funding

Site-Selective Catalysis for Bioactive Scaffold DiversificationR35GM132092 · NIGMS · YALE UNIVERSITY · PI Scott J Miller · 2019 to 2026
$6.3M
Refining & Implementing Supramolecular Methods for HTS of EE & ConcentrationR01GM077437 · NIGMS · UNIVERSITY OF TEXAS AT AUSTIN · PI ANSLYN, ERIC V. · 2006 to 2021
$3.4M
NIGMS NIH HHS R01 GM077437NIGMS NIH HHS R35 GM132092
6 · The paper itself

Abstract

Atropisomeric scaffolds are a common design element found in pharmaceuticals, many deriving from an N-C axis of chirality. The handedness associated with atropisomeric drugs is oftentimes crucial for their efficacy and/or safety. With the increased use of high-throughput screening (HTS) for drug discovery, the need for rapid enantiomeric excess (

Identifiers

PMID37293656
PMCPMC10246677

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.