Evidence map›Paper›PMID 37293603›Full record

ArticleSouthern African journal of HIV medicine2023

Breaking the unbreakable: A paediatric case of dolutegravir resistance from KwaZulu-Natal.

Sibongiseni Malinga, Aabida Khan, Moherndran Archary

Abstract readCase Reports
In one paragraph

Article in Southern African journal of HIV medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Trial
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Sibongiseni MalingaDepartment of Paediatrics, King Edward VIII Hospital, Durban, South Africa.ORCID https://orcid.org/0000-0002-2670-6584
Aabida KhanDepartment of Virology, Inkosi Albert Luthuli Central Hospital, National Health Laboratory Service (NHLS), Durban, South Africa.ORCID https://orcid.org/0000-0002-8738-1867
Moherndran ArcharyDepartment of Paediatrics, King Edward VIII Hospital, Durban, South Africa.ORCID https://orcid.org/0000-0003-3082-9234

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We report a case of dolutegravir resistance in KwaZulu-Natal in a 13-year-old male two years after starting dolutegravir. Resistance most likely developed due to poor adherence as a result of psychosocial issues. This case highlights the importance of the role of the family unit in impacting adherence and close monitoring of treatment-experienced patients with virologic failure following switching to dolutegravir-based regimens.

Indexed as

adolescencedolutegravirDTGHIVpaediatricsresistance

Identifiers

PMID37293603
PMCPMC10244928

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.