Evidence map›Paper›PMID 37293395›Full record

ArticleAmerican journal of ophthalmology case reports2023

Next-generation sequencing of a large uveal melanoma with whole genome doubling and a

Tessnim R Ahmad, Melike Pekmezci, Michele M Bloomer, James P Grenert, Armin R Afshar

Open access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of ophthalmology case reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Tessnim R AhmadDepartment of Ophthalmology, Wayne & Gladys Valley Center for Vision, University of California San Francisco, San Francisco, CA, USA.
Melike PekmezciDepartment of Ophthalmology, Wayne & Gladys Valley Center for Vision, University of California San Francisco, San Francisco, CA, USA.
Michele M BloomerDepartment of Ophthalmology, Wayne & Gladys Valley Center for Vision, University of California San Francisco, San Francisco, CA, USA.
James P GrenertDepartment of Pathology, University of California San Francisco, San Francisco, CA, USA.
Armin R AfsharDepartment of Ophthalmology, Wayne & Gladys Valley Center for Vision, University of California San Francisco, San Francisco, CA, USA.
University of California, San Francisco · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: To report a large uveal melanoma with extra-scleral extension which underwent spontaneous infarction and its unique molecular signature profile. Observations: An 81-year-old female presented with a blind, painful eye. Intraocular pressure was 48 mm Hg. There was a large subconjunctival melanotic mass overlying a choroidal melanoma with anterior extension involving the ciliary body and the iridocorneal angle and iris. Ultrasonography confirmed a dome-shaped anterior cilio-choroidal mass with extra-scleral extension. The patient underwent enucleation and pathologic evaluation confirmed cilio-choroidal melanoma. The posterior half of the tumor involving the ciliary body and the extra-scleral component were spontaneously infarcted and were composed of large melanophages. Next-generation sequencing demonstrated a splice site mutation in Conclusions and importance: This case of a large, auto-infarcted uveal melanoma demonstrates a

Indexed as

Choroidal melanomaMelanomalytic glaucomaNext-generation sequencingUveal melanoma

Identifiers

PMID37293395
PMCPMC10245097
OpenAlexW4378573991

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.